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Table 1 Results of (A) CTC analysis and (B) genomic analysis of CTCs in this case

From: Genomic analysis of circulating tumor cells in adenosquamous carcinoma of the prostate: a case report

(A)

CTC type

Number of detections

CTC-CK+

5 CTCs/10 mL

CTC-CK−

14 CTCs/10 mL

CTC-cluster

8 clusters/10 mL

(B)

Chromosome

Position

Reference

Alteration

Gene

Type of variant, protein change (if any)

Variant classification

CK status

Allele frequency (%)

3

138699065

A

T

PIK3CB

Missense variant, p.L50M, p.L538M

VUS

CK+

5.2

3

138699162

T

G

PIK3CB

Intronic variant

VUS

CK−

21.1

5

112840058

ATT

A

APC

Frameshift variant, p.L1471fs, p.L1489fs

LP

CK+

10.5

9

21974504

G

T

CDKN2A

Intronic variant

VUS

CK−

47.3

10

87925549

ATACAATC

A

PTEN

Frameshift variant, p.Y68fs, p.Y241fs

VUS

CK−

18.4

10

87933078

G

T

PTEN

Missense variant, p.D107Y, p.D280Y

LP

CK−

5.3

13

32362653

T

A

BRCA2

Missense variant, p.C2646S

VUS

CK+

31.6

13

48381316

T

A

RB1

Stop-gain variant, p.L523X

LP

CK−

52.6

17

7673794

C

T

TP53

Missense variant, p.A144T, p.A117T, p.A237T, p.A276T

LP

CK+

2.6

17

7673799

A

G

TP53

Missense variant, p.V142A, p.V115A, p.V235A, p.V274A

LP

CK−

15.7

17

7675161

G

C

TP53

Missense variant, p.P19A, p.P112A, p.P151A

LP

CK−

18.4

17

7676397

AG

A

TP53

Frameshift variant, p.P27fs

LP

CK−

13.2

17

7687968

C

A

TP53

Intronic variant

VUS

CK−

28.9

17

39531218

T

TG

CDK12

Frameshift variant, p.W1450fs, p.W1459fs

LP

CK+

7.9

  1. Bold: Allele frequency > 20%
  2. Abbreviations: CK, cytokeratin; CTC, circulating tumor cell; LP, likely pathogenic; VUS, variant of uncertain significance