Table 4 Relationships of MAD1L1 and TSNARE1 polymorphisms with SCZ risk stratified by age and gender
Gene SIP | Model | Genotype | ≤ 36 | > 36 | Male | Female | ||||
|---|---|---|---|---|---|---|---|---|---|---|
OR (95% CI) | p | OR (95% CI) | p | OR (95% CI) | p | OR (95% CI) | p | |||
MAD1L1 rs10275045 | Allele | C | 1.00 | 1.00 | 1.00 | 1.00 | ||||
T | 0.91 (0.71–1.16) | 0.429 | 1.01 (0.78–1.32) | 0.937 | 0.85 (0.67–1.09) | 0.201 | 1.08 (0.83–1.40) | 0.575 | ||
Codominant | CC | 1.00 | 1.00 | 1.00 | 1.00 | |||||
TT | 0.81 (0.50–1.33) | 0.404 | 1.05 (0.60–1.83) | 0.878 | 0.74 (0.44–1.24) | 0.250 | 1.16 (0.69–1.97) | 0.572 | ||
TC | 1.03 (0.70–1.52) | 0.883 | 0.66 (0.43–1.03) | 0.065 | 0.70 (0.47–1.05) | 0.082 | 1.08 (0.71–1.63) | 0.730 | ||
Dominant | CC | 1.00 | 1.00 | 1.00 | 1.00 | |||||
TT-TC | 0.96 (0.67–1.39) | 0.838 | 0.75 (0.49–1.13) | 0.171 | 0.71 (0.48–1.04) | 0.079 | 1.10 (0.74–1.63) | 0.634 | ||
Recessive | TC-CC | 1.00 | 1.00 | 1.00 | 1.00 | |||||
TT | 0.80 (0.52–1.23) | 0.304 | 1.36 (0.84–2.21) | 0.207 | 0.93 (0.60–1.45) | 0.747 | 1.11 (0.70–1.77) | 0.649 | ||
Additive | – | 0.92 (0.72–1.17) | 0.477 | 0.97 (0.74–1.28) | 0.855 | 0.84 (0.65–1.08) | 0.179 | 1.08 (0.83–1.40) | 0.568 | |
MAD1L1 rs12666575 | Allele | C | 1.00 | 1.00 | 1.00 | 1.00 | ||||
T | 0.98 (0.77–1.24) | 0.853 | 1.05 (0.81–1.37) | 0.707 | 0.95 (0.74–1.22) | 0.691 | 1.08 (0.83–1.40) | 0.566 | ||
Codominant | CC | 1.00 | 1.00 | 1.00 | 1.00 | |||||
TT | 0.99 (0.61–1.61) | 0.974 | 1.17 (0.68–2.02) | 0.563 | 0.92 (0.56–1.50) | 0.728 | 1.29 (0.76–2.18) | 0.342 | ||
TC | 0.91 (0.61–1.35) | 0.645 | 0.64 (0.41–1.00) | 0.048 | 0.86 (0.57–1.30) | 0.472 | 0.70 (0.46–1.06) | 0.093 | ||
Dominant | CC | 1.00 | 1.00 | 1.00 | 1.00 | |||||
TT-TC | 0.93 (0.64–1.36) | 0.722 | 0.77 (0.51–1.16) | 0.210 | 0.88 (0.60–1.29) | 0.504 | 0.83 (0.56–1.24) | 0.371 | ||
Recessive | TC-CC | 1.00 | 1.00 | 1.00 | 1.00 | |||||
TT | 1.05 (0.69–1.60) | 0.817 | 1.55 (0.97–2.48) | 0.064 | 1.01 (0.66–1.54) | 0.975 | 0.61 (0.52–1.15) | 0.042 | ||
Additive | – | 0.99 (0.78–1.26) | 0.923 | 1.04 (0.79–1.36) | 0.791 | 0.95 (0.74–1.22) | 0.682 | 1.08 (0.83–1.40) | 0.560 | |
MAD1L1 rs1107592 | Allele | G | 1.00 | 0.669 | 1.00 | 1.00 | 1.00 | |||
A | 0.95 (0.75–1.21) | 0.97 (0.75–1.26) | 0.809 | 1.08 (0.84–1.37) | 0.561 | 0.84 (0.65–1.09) | 0.185 | |||
Codominant | GG | 1.00 | 1.00 | 1.00 | 1.00 | |||||
AA | 0.92 (0.57–1.49) | 0.731 | 0.99 (0.59–1.69) | 0.980 | 1.20 (0.74–1.94) | 0.452 | 0.73 (0.43–1.23) | 0.239 | ||
AG | 0.82 (0.55–1.21) | 0.312 | 0.62 (0.40–0.96) | 0.034 | 0.82 (0.55–1.22) | 0.325 | 0.62 (0.40–0.95) | 0.029 | ||
Dominant | GG | 1.00 | 1.00 | 1.00 | 1.00 | |||||
AA-AG | 0.85 (0.59–1.22) | 0.376 | 0.72 (0.47–1.09) | 0.120 | 0.93 (0.64–1.34) | 0.691 | 0.65 (0.43–0.98) | 0.038 | ||
Recessive | AG-GG | 1.00 | 1.00 | 1.00 | 1.00 | |||||
AA | 1.04 (0.68–1.58) | 0.860 | 1.35 (0.86–2.11) | 0.193 | 1.35 (0.89–2.06) | 0.157 | 1.00 (0.6–1.56) | 0.992 | ||
Additive | – | 0.94 (0.74–1.20) | 0.635 | 0.97 (0.75–1.26) | 0.827 | 1.07 (0.84–1.36) | 0.580 | 0.84 (0.64–1.09) | 0.179 | |
TSNARE1 rs4976976 | Allele | G | 1.00 | 1.00 | 1.00 | 1.00 | ||||
A | 0.98 (0.77–1.24) | 0.859 | 0.92 (0.71–1.20) | 0.540 | 1.04 (0.81–1.33) | 0.754 | 1.10 (0.85–1.42) | 0.472 | ||
Codominant | GG | 1.00 | 1.00 | 1.00 | 1.00 | |||||
AA | 0.97 (0.60–1.55) | 0.884 | 0.85 (0.50–1.44) | 0.551 | 1.10 (0.67–1.80) | 0.715 | 1.19 (0.72–1.97) | 0.490 | ||
AG | 0.73 (0.48–1.10) | 0.136 | 0.63 (0.40–0.99) | 0.045 | 0.61 (0.40–0.93) | 0.022 | 0.96 (0.62–1.50) | 0.865 | ||
Dominant | GG | 1.00 | 1.00 | 1.00 | 1.00 | |||||
AA-AG | 0.80 (0.54–1.18) | 0.268 | 0.70 (0.46–1.07) | 0.095 | 0.74 (0.49–1.10) | 0.136 | 1.04 (0.69–1.57) | 0.852 | ||
Recessive | AG-GG | 1.00 | 1.00 | 1.00 | 1.00 | |||||
AA | 1.19 (0.80–1.75) | 0.397 | 1.15 (0.74–1.78) | 0.537 | 0.53 (0.42–0.89) | 0.041 | 1.22 (0.81–1.84) | 0.340 | ||
Additive | – | 0.98 (0.77–1.24) | 0.868 | 0.92 (0.70–1.19) | 0.507 | 1.04 (0.82–1.33) | 0.742 | 1.09 (0.85–1.40) | 0.488 | |
TSNARE1 rs67756423 | Allele | A | 1.00 | 1.00 | 1.00 | 1.00 | ||||
C | 0.97 (0.75–1.24) | 0.787 | 0.93 (0.71–1.22) | 0.600 | 0.90 (0.69–1.16) | 0.399 | 1.01 (0.78–1.32) | 0.931 | ||
Codominant | AA | 1.00 | 1.00 | 1.00 | 1.00 | |||||
CC | 1.13 (0.67–1.91) | 0.649 | 1.04 (0.57–1.89) | 0.896 | 1.05 (0.60–1.85) | 0.854 | 1.15 (0.67–2.00) | 0.609 | ||
CA | 0.71 (0.49–1.02) | 0.065 | 0.71 (0.48–1.07) | 0.106 | 0.64 (0.44–0.92) | 0.017 | 0.82 (0.55–1.22) | 0.321 | ||
Dominant | AA | 1.00 | 1.00 | 1.00 | 1.00 | |||||
CC-CA | 0.79 (0.56–1.12) | 0.190 | 0.78 (0.53–1.14) | 0.199 | 0.71 (0.50–1.01) | 0.056 | 0.89 (0.61–1.30) | 0.548 | ||
Recessive | CA-AA | 1.00 | 1.00 | 1.00 | 1.00 | |||||
CC | 1.35 (0.83–2.20) | 0.229 | 1.25 (0.71–2.17) | 0.441 | 1.33 (0.79–2.26) | 0.282 | 1.29 (0.77–2.14) | 0.333 | ||
Additive | – | 0.96 (0.75–1.23) | 0.749 | 0.93 (0.70–1.22) | 0.587 | 0.89 (0.69–1.15) | 0.390 | 1.01 (0.78–1.31) | 0.937 | |