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Table 5 SNP–SNP interaction models of the MAD1L1 and TSNARE1 genes analyzed by the MDR method

From: MAD1L1 and TSNARE gene polymorphisms are associated with schizophrenia susceptibility in the Han Chinese population

Model

Training Bal. Acc

Testing Bal. Acc

CVC

OR (95% CI)

p

TSNARE1 rs67756423

0.547

0.509

6/10

1.45 (1.12–1.86)

0.004

MAD1L1 rs10275045, MAD1L1 rs1107592

0.566

0.508

4/10

2.57 (1.78–3.71)

< 0.0001

MAD1L1 rs10275045, MAD1L1 rs1107592, TSNARE1 rs4976976

0.588

0.550

10/10

2.01 (1.56–2.59)

< 0.0001

MAD1L1 rs10275045, MAD1L1 rs1107592, TSNARE1 rs4976976, TSNARE1rs67756423

0.607

0.548

10/10

2.41 (1.86–3.13)

< 0.0001

MAD1L1 rs10275045, MAD1L1 rs12666575, MAD1L1 rs1107592, TSNARE1 rs4976976, TSNARE1 rs67756423

0.622

0.522

10/10

2.70 (2.09–3.51)

< 0.0001

  1. MDR, multifactor dimensionality reduction; Bal. Acc., balanced accuracy; CVC, cross–validation consistency; OR, odds ratio; CI, confidence interval
  2. p values were calculated using χ2 tests
  3. p < 0.05 indicates statistical significance
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BMC Medical Genomics

ISSN: 1755-8794

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