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Table 3 Overview over SNPs significantly associated with POD in CGAS approach

From: Association between genetic variants of the cholinergic system and postoperative delirium and cognitive dysfunction in elderly patients

Chr SNP Gene name Position OR [95% CI] P-value Adjusted P-value
7 rs8191992 CHRM2 137,016,561 0.61 [0.46; 0.80] < 0.001 0.01
7 rs6962027 CHRM2 137,017,188 1.59 [1.22; 2.09] < 0.001 0.01
11 rs2067482 CHRM4 46,385,217 1.64 [1.10; 2.44] 0.01 0.03
  1. Entered variables into logistic regression analysis: age (years), Charlson Comorbidity Index and duration of anesthesia. Data are expressed as odds ratio (OR) and 95% confidence interval (CI). OR refer to minor allele counts (0, 1, 2). P-values were adjusted for multiple testing by applying the Benjamini–Hochberg method according to the number of SNPs examined per cholinergic gene. Adjusted P ≤ 0.05 was considered as statistically significant
  2. Chr, Chromosome; SNP, single-nucleotide polymorphism