|
Chr
|
SNP
|
Gene name
|
Position
|
OR [95% CI]
|
P-value
|
Adjusted P-value
|
|---|
|
7
|
rs8191992
|
CHRM2
|
137,016,561
|
0.61 [0.46; 0.80]
|
< 0.001
|
0.01
|
|
7
|
rs6962027
|
CHRM2
|
137,017,188
|
1.59 [1.22; 2.09]
|
< 0.001
|
0.01
|
|
11
|
rs2067482
|
CHRM4
|
46,385,217
|
1.64 [1.10; 2.44]
|
0.01
|
0.03
|
- Entered variables into logistic regression analysis: age (years), Charlson Comorbidity Index and duration of anesthesia. Data are expressed as odds ratio (OR) and 95% confidence interval (CI). OR refer to minor allele counts (0, 1, 2). P-values were adjusted for multiple testing by applying the Benjamini–Hochberg method according to the number of SNPs examined per cholinergic gene. Adjusted P ≤ 0.05 was considered as statistically significant
- Chr, Chromosome; SNP, single-nucleotide polymorphism
