Chr | SNP | Gene name | Position | OR [95% CI] | P-value | Adjusted P-value |
|---|
7 | rs8191992 | CHRM2 | 137,016,561 | 0.61 [0.46; 0.80] | < 0.001 | 0.01 |
7 | rs6962027 | CHRM2 | 137,017,188 | 1.59 [1.22; 2.09] | < 0.001 | 0.01 |
11 | rs2067482 | CHRM4 | 46,385,217 | 1.64 [1.10; 2.44] | 0.01 | 0.03 |
- Entered variables into logistic regression analysis: age (years), Charlson Comorbidity Index and duration of anesthesia. Data are expressed as odds ratio (OR) and 95% confidence interval (CI). OR refer to minor allele counts (0, 1, 2). P-values were adjusted for multiple testing by applying the Benjamini–Hochberg method according to the number of SNPs examined per cholinergic gene. Adjusted P ≤ 0.05 was considered as statistically significant
- Chr, Chromosome; SNP, single-nucleotide polymorphism
