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Table 3 Statistical outcome in variant (NEFH p.Ser787Arg) carriers

From: Sequencing of neurofilament genes identified NEFH Ser787Arg as a novel risk variant of sporadic amyotrophic lateral sclerosis in Chinese subjects

Variables Phase I Phase II Combined
sALS (n = 371) Control (n = 711) sALS (n = 300) Control (n = 1076) sALS (n = 671) Control_2 (n = 1787)
No. carriers 5 1 4 1 9 2
MAF 6.73E-03 7.03 E-04 6.67E-03 4.65 E-04 6.71E-03 5.60 E-04
P value 0.02 0.009 0.0003
OR (95% CI) 9.64 (1.12–82.67) 14.43 (1.61–129.40) 12.06 (2.60–55.88)
  1. sALS, sporadic amyotrophic lateral sclerosis; MAF, minor allele frequency; P value, determined using Fisher's exact test; 95% CI, 95% confidence interval