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Table 3 Statistical outcome in variant (NEFH p.Ser787Arg) carriers

From: Sequencing of neurofilament genes identified NEFH Ser787Arg as a novel risk variant of sporadic amyotrophic lateral sclerosis in Chinese subjects

Variables

Phase I

Phase II

Combined

sALS (n = 371)

Control (n = 711)

sALS (n = 300)

Control (n = 1076)

sALS (n = 671)

Control_2 (n = 1787)

No. carriers

5

1

4

1

9

2

MAF

6.73E-03

7.03 E-04

6.67E-03

4.65 E-04

6.71E-03

5.60 E-04

P value

0.02

0.009

0.0003

OR (95% CI)

9.64 (1.12–82.67)

14.43 (1.61–129.40)

12.06 (2.60–55.88)

  1. sALS, sporadic amyotrophic lateral sclerosis; MAF, minor allele frequency; P value, determined using Fisher's exact test; 95% CI, 95% confidence interval
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BMC Medical Genomics

ISSN: 1755-8794

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