A missense variant rs2585405 in clock gene PER1 is associated with the increased risk of noise-induced hearing loss in a Chinese occupational population

Chen, Hao; Ding, Xuexue; Ding, Enmin; Chen, Mengyao; Wang, Huimin; Yang, Guangzhi; Zhu, Baoli

doi:10.1186/s12920-021-01075-x

Table 3 Distribution of selected SNPs and the association with NIHL

From: A missense variant rs2585405 in clock gene PER1 is associated with the increased risk of noise-induced hearing loss in a Chinese occupational population

Gene	Genetic models	Genotypes	Cases		Controls		P^a	FDR	Adjusted OR (95%CI)^b
Gene	Genetic models	Genotypes	n = 432	%	n = 837	%	P^a	FDR	Adjusted OR (95%CI)^b
PER1	rs2585405
	Codominant	GG	98	22.7	140	16.7	0.03	0.36	1.00 (Ref.)
		GC	198	45.8	425	50.8			1.41 (1.01–1.96)
		CC	136	31.5	272	32.5			0.93 (0.71–1.21)
	Dominant	GG	98	22.7	140	16.7	0.01	0.12	1.00 (Ref.)
		GC/CC	334	77.3	697	83.3			1.47 (1.10–1.97)
	Recessive	GG/GC	296	68.5	565	67.5	0.71	0.97	1.00 (Ref.)
		CC	136	31.5	272	32.5			1.05 (0.82–1.34)
	Alleles	G	194	31.0	705	55.6	0.09	0.88	1.00 (Ref.)
		C	470	37.0	969	76.4			1.15 (0.98–1.36)
	rs2253820
	Codominant	GG	44	10.2	96	11.5	0.45	0.98	1.00 (Ref.)
		AG	196	45.4	399	47.7			0.82 (0.55–1.22)
		AA	192	44.4	342	40.9			0.87 (0.68–1.12)
	Dominant	GG	44	10.2	96	11.5	0.49	0.95	1.00 (Ref.)
		AA/AG	388	89.8	741	88.5			0.88 (0.60–1.28)
	Recessive	AG/GG	240	55.6	495	59.1	0.22	0.97	1.00 (Ref.)
		AA	192	44.4	342	40.9			0.86 (0.68–1.09)
	Alleles	G	284	22.4	591	46.6	0.22	0.88	1.00 (Ref.)
		A	580	45.7	1083	85.3			0.89 (0.75–1.07)
PER2	rs56386336
	Codominant	GG	332	76.9	661	79.0	0.50	0.98	1.00 (Ref.)
		AG	96	22.2	165	19.7			1.26 (0.40–4.02)
		AA	4	0.9	11	1.3			1.47 (0.45–4.78)
	Dominant	GG	332	76.9	661	79.0	0.39	0.95	1.00 (Ref.)
		AG/GG	100	23.1	176	21.0			0.88 (0.66–1.16)
	Recessive	GG/AG	428	99.1	826	98.7	0.54	0.97	1.00 (Ref.)
		AA	4	0.9	11	1.3			1.31 (0.41–4.15)
	Alleles	G	760	59.9	1487	117.1	0.52	0.90	1.00 (Ref.)
		A	104	8.2	187	14.7			1.10 (0.85–1.43)
	rs934945
	Codominant	GG	242	56.0	458	54.7	0.75	0.99	1.00 (Ref.)
		AG	157	36.3	305	36.4			1.19 (0.77–1.85)
		AA	33	7.6	74	8.8			1.16 (0.73–1.82)
	Dominant	GG	242	56.0	458	54.7	0.66	0.95	1.00 (Ref.)
		AG/AA	190	44.0	379	45.3			1.06 (0.84–1.34)
	Recessive	AG/GG	399	92.4	763	91.2	0.47	0.97	1.00 (Ref.)
		AA	33	7.6	74	8.8			1.18 (0.77–1.81)
	Alleles	G	641	50.5	1221	96.2	0.50	0.90	1.00 (Ref.)
		A	223	17.6	453	35.7			0.94 (0.78–1.13)
CRY1	rs1056560
	Codominant	GG	25	5.8	54	6.5	0.37	0.98	1.00 (Ref.)
		GT	143	33.1	306	36.6			0.83 (0.51–1.37)
		TT	264	61.1	477	57.0			0.84 (0.66–1.08)
	Dominant	GG	25	5.8	54	6.5	0.64	0.95	1.00 (Ref.)
		GT/TT	407	94.2	783	93.5			0.89 (0.54–1.45)
	Recessive	GT/GG	168	38.9	360	43.0	0.16	0.97	1.00 (Ref.)
		TT	264	61.1	477	57.0			0.84 (0.66–1.07)
	Alleles	G	193	15.2	414	326	0.18	0.88	1.00 (Ref.)
		T	671	52.9	1260	99.3			0.88 (0.72–1.06)
	rs3809236
	Codominant	CC	276	63.9	514	61.4	0.59	0.98	1.00 (Ref.)
		TC	139	32.2	282	33.7			1.32 (0.73–2.37)
		TT	17	3.9	41	4.9			1.21 (0.66–2.22)
	Dominant	CC	276	63.9	514	61.4	0.39	0.95	1.00 (Ref.)
		TC/TT	156	36.1	323	38.6			1.11 (0.87–1.42)
	Recessive	TC/CC	415	96.1	796	95.1	0.44	0.97	1.00 (Ref.)
		TT	17	3.9	41	4.9			1.28 (0.72–2.29)
	Alleles	C	691	54.5	1310	103.2	0.31	0.90	1.00 (Ref.)
		T	173	13.6	364	28.7			0.90 (0.73–1.10)
CRY2	rs2292910
	Codominant	CC	36	8.3	75	9.0	0.90	0.99	1.00 (Ref.)
		AC	180	41.7	340	40.6			0.93 (0.61–1.43)
		AA	216	50.0	422	50.4			1.04 (0.81–1.32)
	Dominant	CC	36	8.3	75	9.0	0.71	0.95	1.00 (Ref.)
		AC/AA	396	91.7	762	91.0			0.92 (0.61–1.39)
	Recessive	AC/CC	216	50.0	415	49.6	0.89	0.97	1.00 (Ref.)
		AA	216	50.0	422	50.4			1.02 (0.81–1.28)
	Alleles	C	252	19.9	490	38.6	0.96	0,99	1.00 (Ref.)
		A	612	48.2	1184	93.3			0.99 (0.83–1.19)
	rs6798
	Codominant	CC	82	19.0	173	20.7	0.60	0.98	1.00 (Ref.)
		TC	218	50.5	398	47.6			0.96 (0.69–1.35)
		TT	132	30.6	266	31.8			1.10 (0.84–1.44)
	Dominant	CC	82	19.0	173	20.7	0.48	0.95	1.00 (Ref.)
		TC/TT	350	81.0	664	79.3			0.91 (0.68–1.22)
	Recessive	TC/CC	300	69.4	571	68.2	0.66	0.97	1.00 (Ref.)
		TT	132	30.6	266	31.8			1.06 (0.82–1.37)
	Alleles	C	382	30.1	744	58.6	0.91	0.99	1.00 (Ref.)
		T	482	38.0	930	73.3			0.99 (0.84–1.17)
BDNF	rs11030099
	Codominant	CC	139	32.2	250	29.9	0.65	0.98	1.00 (Ref.)
		AC	195	45.1	398	47.6			1.08 (0.78–1.48)
		AA	98	22.7	189	22.6			0.95 (0.70–1.28)
	Dominant	CC	139	32.2	250	29.9	0.40	0.95	1.00 (Ref.)
		AC/AA	293	67.8	587	70.1			1.11 (0.87–1.43)
	Recessive	AC/CC	334	77.3	648	77.4	0.97	0.97	1.00 (Ref.)
		AA	98	22.7	189	22.6			1.00 (0.76–1.32)
	Alleles	C	473	37.3	898	70.8	0.60	0.90	1.00 (Ref.)
		A	391	30.8	776	61.2			0.96 (0.82–1.12)
	rs7124442
	Codominant	CC	1	0.2	2	0.2	0.95	0.99	1.00 (Ref.)
		TC	58	13.4	107	12.8			0.89 (0.08–9.93)
		TT	373	86.3	728	87.0			1.06 (0.75–1.50)
	Dominant	CC	1	0.2	2	0.2	1.00	1.00	1.00 (Ref.)
		TC/TT	431	99.8	835	99.8			0.88 (0.08–9.85)
	Recessive	TC/CC	59	13.7	109	13.0	0.75	0.97	1.00 (Ref.)
		TT	373	86.3	728	87.0			1.06 (0.75–1.49)
	Alleles	C	60	4.7	111	8.7	0.77	0.99	1.00 (Ref.)
		T	804	63.4	1563	123.2			1.05 (0.75–1.46)
	rs6265
	Codominant	GG	125	28.9	240	28.7	0.99	0.99	1.00 (Ref.)
		AG	204	47.2	399	47.7			1.00 (0.73–1.38)
		AA	103	23.8	198	23.7			0.99 (0.74–1.33)
	Dominant	GG	125	28.9	240	28.7	0.92	1.00	1.00 (Ref.)
		AA/AG	307	71.1	597	71.3			1.01 (0.78–1.30)
	Recessive	AG/GG	329	76.2	639	76.3	0.94	0.97	1.00 (Ref.)
		AA	103	23.8	198	23.7			0.99 (0.76–1.31)
	Alleles	G	454	35.8	879	69.3	0.99	0.99	1.00 (Ref.)
		A	410	32.3	795	62.6			1.00 (0.85–1.17)
NTF3	rs1805149
	Codominant	AA	97	22.5	188	22.5	0.54	0.98	1.00 (Ref.)
		AG	67	15.5	111	13.3			1.02 (0.76–1.36)
		GG	268	62.0	538	64.3			1.20 (0.86–1.69)
	Dominant	AA	97	22.5	188	22.5	1.00	1.00	1.00 (Ref.)
		AG/GG	335	77.5	649	77.5			0.98 (0.74–1.30)
	Recessive	AG/AA	164	38.0	299	35.7	0.43	0.97	1.00 (Ref.)
		GG	268	62.0	538	64.3			0.50 (1.09–0.85)
	Alleles	A	261	20.6	487	38.4	0.56	0.90	1.00 (Ref.)
		G	603	47.5	1187	93.6			1.02 (0.89–1.18)

^aTwo-sided χ² test
^bAdjusted for age, sex, alcohol, and tobacco use in a logistic regression model

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