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Table 3 Distribution of selected SNPs and the association with NIHL

From: A missense variant rs2585405 in clock gene PER1 is associated with the increased risk of noise-induced hearing loss in a Chinese occupational population

Gene Genetic models Genotypes Cases Controls Pa FDR Adjusted OR
(95%CI)b
n = 432 % n = 837 %
PER1 rs2585405         
  Codominant GG 98 22.7 140 16.7 0.03 0.36 1.00 (Ref.)
   GC 198 45.8 425 50.8    1.41 (1.01–1.96)
   CC 136 31.5 272 32.5    0.93 (0.71–1.21)
  Dominant GG 98 22.7 140 16.7 0.01 0.12 1.00 (Ref.)
   GC/CC 334 77.3 697 83.3    1.47 (1.10–1.97)
  Recessive GG/GC 296 68.5 565 67.5 0.71 0.97 1.00 (Ref.)
   CC 136 31.5 272 32.5    1.05 (0.82–1.34)
  Alleles G 194 31.0 705 55.6 0.09 0.88 1.00 (Ref.)
   C 470 37.0 969 76.4    1.15 (0.98–1.36)
  rs2253820         
  Codominant GG 44 10.2 96 11.5 0.45 0.98 1.00 (Ref.)
   AG 196 45.4 399 47.7    0.82 (0.55–1.22)
   AA 192 44.4 342 40.9    0.87 (0.68–1.12)
  Dominant GG 44 10.2 96 11.5 0.49 0.95 1.00 (Ref.)
   AA/AG 388 89.8 741 88.5    0.88 (0.60–1.28)
  Recessive AG/GG 240 55.6 495 59.1 0.22 0.97 1.00 (Ref.)
   AA 192 44.4 342 40.9    0.86 (0.68–1.09)
  Alleles G 284 22.4 591 46.6 0.22 0.88 1.00 (Ref.)
   A 580 45.7 1083 85.3    0.89 (0.75–1.07)
PER2 rs56386336         
  Codominant GG 332 76.9 661 79.0 0.50 0.98 1.00 (Ref.)
   AG 96 22.2 165 19.7    1.26 (0.40–4.02)
   AA 4 0.9 11 1.3    1.47 (0.45–4.78)
  Dominant GG 332 76.9 661 79.0 0.39 0.95 1.00 (Ref.)
   AG/GG 100 23.1 176 21.0    0.88 (0.66–1.16)
  Recessive GG/AG 428 99.1 826 98.7 0.54 0.97 1.00 (Ref.)
   AA 4 0.9 11 1.3    1.31 (0.41–4.15)
  Alleles G 760 59.9 1487 117.1 0.52 0.90 1.00 (Ref.)
   A 104 8.2 187 14.7    1.10 (0.85–1.43)
  rs934945         
  Codominant GG 242 56.0 458 54.7 0.75 0.99 1.00 (Ref.)
   AG 157 36.3 305 36.4    1.19 (0.77–1.85)
   AA 33 7.6 74 8.8    1.16 (0.73–1.82)
  Dominant GG 242 56.0 458 54.7 0.66 0.95 1.00 (Ref.)
   AG/AA 190 44.0 379 45.3    1.06 (0.84–1.34)
  Recessive AG/GG 399 92.4 763 91.2 0.47 0.97 1.00 (Ref.)
   AA 33 7.6 74 8.8    1.18 (0.77–1.81)
  Alleles G 641 50.5 1221 96.2 0.50 0.90 1.00 (Ref.)
   A 223 17.6 453 35.7    0.94 (0.78–1.13)
CRY1 rs1056560         
  Codominant GG 25 5.8 54 6.5 0.37 0.98 1.00 (Ref.)
   GT 143 33.1 306 36.6    0.83 (0.51–1.37)
   TT 264 61.1 477 57.0    0.84 (0.66–1.08)
  Dominant GG 25 5.8 54 6.5 0.64 0.95 1.00 (Ref.)
   GT/TT 407 94.2 783 93.5    0.89 (0.54–1.45)
  Recessive GT/GG 168 38.9 360 43.0 0.16 0.97 1.00 (Ref.)
   TT 264 61.1 477 57.0    0.84 (0.66–1.07)
  Alleles G 193 15.2 414 326 0.18 0.88 1.00 (Ref.)
   T 671 52.9 1260 99.3    0.88 (0.72–1.06)
  rs3809236         
  Codominant CC 276 63.9 514 61.4 0.59 0.98 1.00 (Ref.)
   TC 139 32.2 282 33.7    1.32 (0.73–2.37)
   TT 17 3.9 41 4.9    1.21 (0.66–2.22)
  Dominant CC 276 63.9 514 61.4 0.39 0.95 1.00 (Ref.)
   TC/TT 156 36.1 323 38.6    1.11 (0.87–1.42)
  Recessive TC/CC 415 96.1 796 95.1 0.44 0.97 1.00 (Ref.)
   TT 17 3.9 41 4.9    1.28 (0.72–2.29)
  Alleles C 691 54.5 1310 103.2 0.31 0.90 1.00 (Ref.)
   T 173 13.6 364 28.7    0.90 (0.73–1.10)
CRY2 rs2292910         
  Codominant CC 36 8.3 75 9.0 0.90 0.99 1.00 (Ref.)
   AC 180 41.7 340 40.6    0.93 (0.61–1.43)
   AA 216 50.0 422 50.4    1.04 (0.81–1.32)
  Dominant CC 36 8.3 75 9.0 0.71 0.95 1.00 (Ref.)
   AC/AA 396 91.7 762 91.0    0.92 (0.61–1.39)
  Recessive AC/CC 216 50.0 415 49.6 0.89 0.97 1.00 (Ref.)
   AA 216 50.0 422 50.4    1.02 (0.81–1.28)
  Alleles C 252 19.9 490 38.6 0.96 0,99 1.00 (Ref.)
   A 612 48.2 1184 93.3    0.99 (0.83–1.19)
  rs6798         
  Codominant CC 82 19.0 173 20.7 0.60 0.98 1.00 (Ref.)
   TC 218 50.5 398 47.6    0.96 (0.69–1.35)
   TT 132 30.6 266 31.8    1.10 (0.84–1.44)
  Dominant CC 82 19.0 173 20.7 0.48 0.95 1.00 (Ref.)
   TC/TT 350 81.0 664 79.3    0.91 (0.68–1.22)
  Recessive TC/CC 300 69.4 571 68.2 0.66 0.97 1.00 (Ref.)
   TT 132 30.6 266 31.8    1.06 (0.82–1.37)
  Alleles C 382 30.1 744 58.6 0.91 0.99 1.00 (Ref.)
   T 482 38.0 930 73.3    0.99 (0.84–1.17)
BDNF rs11030099         
  Codominant CC 139 32.2 250 29.9 0.65 0.98 1.00 (Ref.)
   AC 195 45.1 398 47.6    1.08 (0.78–1.48)
   AA 98 22.7 189 22.6    0.95 (0.70–1.28)
  Dominant CC 139 32.2 250 29.9 0.40 0.95 1.00 (Ref.)
   AC/AA 293 67.8 587 70.1    1.11 (0.87–1.43)
  Recessive AC/CC 334 77.3 648 77.4 0.97 0.97 1.00 (Ref.)
   AA 98 22.7 189 22.6    1.00 (0.76–1.32)
  Alleles C 473 37.3 898 70.8 0.60 0.90 1.00 (Ref.)
   A 391 30.8 776 61.2    0.96 (0.82–1.12)
  rs7124442         
  Codominant CC 1 0.2 2 0.2 0.95 0.99 1.00 (Ref.)
   TC 58 13.4 107 12.8    0.89 (0.08–9.93)
   TT 373 86.3 728 87.0    1.06 (0.75–1.50)
  Dominant CC 1 0.2 2 0.2 1.00 1.00 1.00 (Ref.)
   TC/TT 431 99.8 835 99.8    0.88 (0.08–9.85)
  Recessive TC/CC 59 13.7 109 13.0 0.75 0.97 1.00 (Ref.)
   TT 373 86.3 728 87.0    1.06 (0.75–1.49)
  Alleles C 60 4.7 111 8.7 0.77 0.99 1.00 (Ref.)
   T 804 63.4 1563 123.2    1.05 (0.75–1.46)
  rs6265         
  Codominant GG 125 28.9 240 28.7 0.99 0.99 1.00 (Ref.)
   AG 204 47.2 399 47.7    1.00 (0.73–1.38)
   AA 103 23.8 198 23.7    0.99 (0.74–1.33)
  Dominant GG 125 28.9 240 28.7 0.92 1.00 1.00 (Ref.)
   AA/AG 307 71.1 597 71.3    1.01 (0.78–1.30)
  Recessive AG/GG 329 76.2 639 76.3 0.94 0.97 1.00 (Ref.)
   AA 103 23.8 198 23.7    0.99 (0.76–1.31)
  Alleles G 454 35.8 879 69.3 0.99 0.99 1.00 (Ref.)
   A 410 32.3 795 62.6    1.00 (0.85–1.17)
NTF3 rs1805149         
  Codominant AA 97 22.5 188 22.5 0.54 0.98 1.00 (Ref.)
   AG 67 15.5 111 13.3    1.02 (0.76–1.36)
   GG 268 62.0 538 64.3    1.20 (0.86–1.69)
  Dominant AA 97 22.5 188 22.5 1.00 1.00 1.00 (Ref.)
   AG/GG 335 77.5 649 77.5    0.98 (0.74–1.30)
  Recessive AG/AA 164 38.0 299 35.7 0.43 0.97 1.00 (Ref.)
   GG 268 62.0 538 64.3    0.50 (1.09–0.85)
  Alleles A 261 20.6 487 38.4 0.56 0.90 1.00 (Ref.)
   G 603 47.5 1187 93.6    1.02 (0.89–1.18)
  1. aTwo-sided χ2 test
  2. bAdjusted for age, sex, alcohol, and tobacco use in a logistic regression model