A missense variant rs2585405 in clock gene PER1 is associated with the increased risk of noise-induced hearing loss in a Chinese occupational population

Table 4 Stratified analyses of rs2585405 polymorphism and NIHL risk

Group	Genotype	noise exposed (years)		Expose level with noise (dB)
Group	Genotype	≤ 16	> 16	≤ 85	85–92	> 92
Case	GG	27	71	63	26	9
	GC	33	165	124	59	15
	CC	24	112	78	41	17
Control	GG	34	106	76	55	9
	GC	80	345	248	139	38
	CC	55	217	150	94	28
P^a		0.11	0.17	0.03	0.93	0.23
Adjusted OR		1.33	1.11	1.23	1.02	1.07
(95%CI)^b		(0.93–1.90)	(0.92–1.34)	(0.99–1.53)	(0.76–1.37)	(0.61–1.87)
Case	GG	27	71	63	26	9
	GC/CC	57	277	202	100	32
Control	GG	34	106	76	55	9
	GC/CC	135	562	398	233	66
P^a		0.04	0.07	0.01	0.72	0.16
Adjusted OR		1.88	1.37	1.64	1.10	1.92
(95%CI)^b		(1.03–3.42)	(0.98–1.91)	(1.12–2.38)	(0.65–1.85)	(0.67–5.52)

ISSN: 1755-8794