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Fig. 4 | BMC Medical Genomics

Fig. 4

From: Lung disease network reveals impact of comorbidity on SARS-CoV-2 infection and opportunities of drug repurposing

Fig. 4

Network-based separation (\({S}_{ab}\)) and pathobiological similarities. aj shows observed \({S}_{ab}\), z-score (red arrow) and distribution of \({S}_{ab}^{ran}\) of top 10 overlapping lung diseases with COVID-19 (here, ARMCM indicates abnormal respiratory motile cilium morphology). k Box plot represents the pairwise correlation between genes is significantly (p-value < 0.0001) higher than the random gene sets. l, m Box plots show the distribution of functional similarities (MF) and GO processes (BP) between the genes involved in lung disease and COVID-19. The GO processes and functional similarity between the genes are significantly high (p < 0.0001) compared to the random gene sets (note, in figures k, l, and m 1–10 indicates disease in a similar sequence as it is mentioned in figures a to j). n The strategy of drug repurposing to target the COVID19 module

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