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Table 3 The effect estimates, test of heterogeneity and test of pleiotropy of exposure on cholecystitis

From: Mendelian randomization rules out the causal relationship between serum lipids and cholecystitis

 

MR methodology

Effect estimates on cholecystitis

Test of heterogeneity

Test of pleiotropy

p value

OR

Lower

Upper

p value

Cochrane Q test

p value

MR-Egger intercept

Total cholesterol

Inverse variance weighted (multiplicative random effects)

0.9994228

0.9994222

0.9994233

0.2960

135.009

0.053

  
 

MR Egger

0.9987183

0.9987161

0.9987205

0.1893

133.856

0.053

0.0000406

0.335

 

Inverse variance weighted (fixed effects)

0.9994228

0.9994223

0.9994232

0.2347

135.009

0.053

  
 

Weighted median

0.9994726

0.9994719

0.9994733

0.5640

    

HDL-C

Inverse variance weighted (multiplicative random effects)

0.9997020

0.9997017

0.9997023

0.5650

188.737

0.000

  
 

MR Egger

0.9988892

0.9988871

0.9988913

0.2510

187.188

0.000

0.0000446

0.319

 

Inverse variance weighted (fixed effects)

0.9997020

0.9997018

0.9997023

0.4740

188.737

0.000

  
 

Weighted median

0.9996111

0.9996106

0.9996117

0.5870

    

LDL-C

Inverse variance weighted (multiplicative random effects)

0.9984483

0.9984499

0.9984468

0.0080

116.489188

0.004851838

  
 

MR Egger

0.9987160

0.9987180

0.9987140

0.1893

116.200524

0.004109598

− 0.000021

0.658974602

 

Inverse variance weighted (fixed effects)

0.9984483

0.9984496

0.9984471

0.0008

116.489188

0.004851838

  
 

Weighted median

0.9991214

0.9991225

0.9991203

0.3380

    

Triglycerides

Inverse variance weighted (multiplicative random effects)

0.9990893

0.9990882

0.9990903

0.2380

96.010

0.021

  
 

MR Egger

0.9980924

0.9980889

0.9980958

0.1680

93.378

0.027

0.0000655

0.168

 

Inverse variance weighted (fixed effects)

0.9990893

0.9990884

0.9990902

0.1360

96.010

0.021

  
 

Weighted median

0.9983449

0.9983424

0.9983474

0.1360

    
  1. TC total cholesterol, HDL-C HDL cholesterol, LDL-C LDL cholesterol, TG triglycerides, OR odds ratio, upper upper bounds of 95% confidence interval, lower lower bounds of 95% confidence interval. p value was adjusted by false discovery rate approach