From: Mendelian randomization rules out the causal relationship between serum lipids and cholecystitis
MR methodology | Effect estimates on cholecystitis | Test of heterogeneity | Test of pleiotropy | p value | |||||
---|---|---|---|---|---|---|---|---|---|
OR | Lower | Upper | p value | Cochrane Q test | p value | MR-Egger intercept | |||
Total cholesterol | Inverse variance weighted (multiplicative random effects) | 0.9994228 | 0.9994222 | 0.9994233 | 0.2960 | 135.009 | 0.053 | ||
MR Egger | 0.9987183 | 0.9987161 | 0.9987205 | 0.1893 | 133.856 | 0.053 | 0.0000406 | 0.335 | |
Inverse variance weighted (fixed effects) | 0.9994228 | 0.9994223 | 0.9994232 | 0.2347 | 135.009 | 0.053 | |||
Weighted median | 0.9994726 | 0.9994719 | 0.9994733 | 0.5640 | |||||
HDL-C | Inverse variance weighted (multiplicative random effects) | 0.9997020 | 0.9997017 | 0.9997023 | 0.5650 | 188.737 | 0.000 | ||
MR Egger | 0.9988892 | 0.9988871 | 0.9988913 | 0.2510 | 187.188 | 0.000 | 0.0000446 | 0.319 | |
Inverse variance weighted (fixed effects) | 0.9997020 | 0.9997018 | 0.9997023 | 0.4740 | 188.737 | 0.000 | |||
Weighted median | 0.9996111 | 0.9996106 | 0.9996117 | 0.5870 | |||||
LDL-C | Inverse variance weighted (multiplicative random effects) | 0.9984483 | 0.9984499 | 0.9984468 | 0.0080 | 116.489188 | 0.004851838 | ||
MR Egger | 0.9987160 | 0.9987180 | 0.9987140 | 0.1893 | 116.200524 | 0.004109598 | − 0.000021 | 0.658974602 | |
Inverse variance weighted (fixed effects) | 0.9984483 | 0.9984496 | 0.9984471 | 0.0008 | 116.489188 | 0.004851838 | |||
Weighted median | 0.9991214 | 0.9991225 | 0.9991203 | 0.3380 | |||||
Triglycerides | Inverse variance weighted (multiplicative random effects) | 0.9990893 | 0.9990882 | 0.9990903 | 0.2380 | 96.010 | 0.021 | ||
MR Egger | 0.9980924 | 0.9980889 | 0.9980958 | 0.1680 | 93.378 | 0.027 | 0.0000655 | 0.168 | |
Inverse variance weighted (fixed effects) | 0.9990893 | 0.9990884 | 0.9990902 | 0.1360 | 96.010 | 0.021 | |||
Weighted median | 0.9983449 | 0.9983424 | 0.9983474 | 0.1360 |