Skip to main content

Table 2 Linear regression models of associations between sleep duration and the GABAA receptor genes GABRB3, GABRA5, and GABRG3

From: An association study in the Taiwan Biobank elicits the GABAA receptor genes GABRB3, GABRA5, and GABRG3 as candidate loci for sleep duration in the Taiwanese population

Gene Chr SNP A1 A2 Region MAF Dominant model Recessive model Genotypic model
Beta SE P Beta SE P Beta SE P
GABRB3 15 rs150101078 A G Intron 0.040 0.13 0.04 2.61 × 10−3 0.01 0.28 0.985 0.01 0.14 0.956
   rs12438141 T C Missense 0.059 0.07 0.04 0.034  − 0.02 0.19 0.927 0.00 0.10 0.962
   rs79565260 A G Intron 0.178 0.03 0.02 0.230 0.06 0.06 0.365 0.03 0.03 0.310
   rs149646336 T C Intron 0.027 0.00 0.05 0.939 0.15 0.43 0.728 0.07 0.21 0.728
   rs74591460 C A Intron 0.099  − 0.01 0.03 0.861 0.22 0.11 0.040 0.11 0.05 0.043
   rs79465949 T C Intron 0.018 0.01 0.06 0.839 0.65 0.56 0.249 0.32 0.28 0.249
   rs74004636 T G Intron 0.057  − 0.01 0.04 0.850  − 0.44 0.20 0.024  − 0.22 0.10 0.024
   rs79333046 A G Intron 0.213  − 0.07 0.02 1.21 × 10−3  − 0.07 0.06 0.207  − 0.05 0.03 0.088
   rs76635931 G T Intron 0.014 0.09 0.07 0.187  − 1.08 1.13 0.335 NA NA NA
   rs111863451 G T Intron 0.027  − 0.02 0.05 0.685 0.80 0.40 0.045 0.40 0.20 0.046
   rs145333058 T C Intron 0.015 0.02 0.07 0.716  − 0.54 0.80 0.495  − 0.27 0.40 0.495
   rs146937293 C T Intron 0.043 0.01 0.04 0.770 0.09 0.23 0.709 0.04 0.12 0.707
   rs77328500 G A Intron 0.077  − 0.02 0.03 0.442 0.03 0.15 0.860 0.01 0.08 0.879
   rs74653915 C T Intron 0.016  − 0.11 0.06 0.103 0.02 0.80 0.980 0.01 0.40 0.984
GABRA5 15 rs78575803 A G Intron 0.101 0.02 0.03 0.498 0.11 0.10 0.297 0.06 0.05 0.287
   rs7165524 T C Intron 0.270  − 0.02 0.02 0.311  − 0.02 0.04 0.721  − 0.01 0.02 0.573
   rs80063633 A C Intron 0.151 0.00 0.02 0.949 0.15 0.07 0.045 0.07 0.04 0.049
   rs140148185 A G Intron 0.090  − 0.01 0.03 0.809 0.39 0.13 2.73 × 10−3 0.19 0.06 3.05 × 10−3
   rs146013014 G A Intron 0.026 0.07 0.05 0.182 0.55 0.40 0.163 0.28 0.20 0.161
   rs189790076 C G Intron 0.016 0.06 0.06 0.316 1.84 0.56 1.05 × 10−3 0.92 0.28 1.04 × 10−3
   rs140319999 T C Intron 0.018 0.10 0.06 0.103  − 0.17 0.80 0.827  − 0.09 0.40 0.831
   rs34560927 T C Intron 0.372 0.00 0.02 0.988 0.06 0.03 0.091 0.02 0.02 0.174
GABRG3 15 rs34984550 G C Intron 0.024 0.00 0.05 0.941  − 0.18 0.56 0.752  − 0.09 0.28 0.752
   rs140670 A T Intron 0.293 0.01 0.02 0.664  − 0.03 0.04 0.455  − 0.01 0.02 0.586
   rs147619342 T C Intron 0.017  − 0.08 0.06 0.208  − 1.45 0.50 4.02 × 10−3  − 0.72 0.25 3.97 × 10−3
   rs12903002 T C Intron 0.088 0.02 0.03 0.490 0.01 0.13 0.921 0.01 0.07 0.901
   rs1017364 G A Intron 0.266 0.03 0.02 0.217  − 0.01 0.04 0.813 0.00 0.02 0.946
   rs150722146 A G Intron 0.026  − 0.05 0.05 0.282  − 0.29 0.56 0.604  − 0.15 0.28 0.601
   rs138047237 A G Intron 0.013 0.06 0.07 0.384 1.30 0.80 0.103 0.65 0.40 0.103
   rs734254 A G Intron 0.034  − 0.11 0.05 0.018  − 0.33 0.34 0.325  − 0.17 0.17 0.316
   rs12593313 G C Intron 0.022 0.00 0.06 0.989  − 0.01 0.43 0.990 0.00 0.21 0.990
   rs140853604 T C Intron 0.031  − 0.01 0.05 0.789 0.32 0.37 0.387 0.16 0.19 0.389
   rs7173587 T C Intron 0.157  − 0.06 0.02 0.023 0.08 0.07 0.288 0.03 0.04 0.419
   rs143682098 G A Intron 0.053  − 0.02 0.04 0.679  − 0.12 0.25 0.645  − 0.06 0.13 0.641
   rs17739682 G A Intron 0.072 0.02 0.03 0.620 0.12 0.17 0.489 0.06 0.08 0.483
   rs144369966 C T Intron 0.018 0.06 0.06 0.316  − 0.29 0.65 0.653  − 0.14 0.32 0.656
   rs67338000 A G Intron 0.449  − 0.04 0.02 0.068 0.00 0.03 0.859  − 0.01 0.02 0.401
   rs8028000 C T Intron 0.014  − 0.14 0.07 0.041  − 1.64 0.80 0.039  − 0.82 0.40 0.039
   rs61507711 T C Intron 0.097 0.02 0.03 0.582 0.10 0.12 0.384 0.05 0.06 0.376
   rs9302372 A G Intron 0.042 0.02 0.04 0.670  − 0.08 0.23 0.740  − 0.04 0.12 0.745
   rs4555109 T G Intron 0.222 0.04 0.02 0.104 0.01 0.05 0.825 0.01 0.03 0.624
   rs149403614 A G Intron 0.035 0.00 0.04 0.994 0.05 0.40 0.894 0.03 0.20 0.894
   rs28399529 G A 3′ UTR 0.022 0.00 0.06 0.965  − 0.25 0.65 0.705  − 0.12 0.33 0.705
  1. Analysis was obtained after adjustment for covariates, including age, gender, physical activity, coffee consumption, tea consumption, smoking, alcohol consumption, body mass index (BMI), and status of chronic disorders
  2. P values < 0.05 represent the significant values and are shown in bold
  3. A1 minor allele, A2 major allele, GABAA gamma-aminobutyric acid type A, Beta Beta coefficients, Chr chromosome, MAF minor allele frequency, NA not available, SE standard error