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Table 2 Linear regression models of associations between sleep duration and the GABAA receptor genes GABRB3, GABRA5, and GABRG3

From: An association study in the Taiwan Biobank elicits the GABAA receptor genes GABRB3, GABRA5, and GABRG3 as candidate loci for sleep duration in the Taiwanese population

Gene

Chr

SNP

A1

A2

Region

MAF

Dominant model

Recessive model

Genotypic model

Beta

SE

P

Beta

SE

P

Beta

SE

P

GABRB3

15

rs150101078

A

G

Intron

0.040

0.13

0.04

2.61 × 10−3

0.01

0.28

0.985

0.01

0.14

0.956

  

rs12438141

T

C

Missense

0.059

0.07

0.04

0.034

 − 0.02

0.19

0.927

0.00

0.10

0.962

  

rs79565260

A

G

Intron

0.178

0.03

0.02

0.230

0.06

0.06

0.365

0.03

0.03

0.310

  

rs149646336

T

C

Intron

0.027

0.00

0.05

0.939

0.15

0.43

0.728

0.07

0.21

0.728

  

rs74591460

C

A

Intron

0.099

 − 0.01

0.03

0.861

0.22

0.11

0.040

0.11

0.05

0.043

  

rs79465949

T

C

Intron

0.018

0.01

0.06

0.839

0.65

0.56

0.249

0.32

0.28

0.249

  

rs74004636

T

G

Intron

0.057

 − 0.01

0.04

0.850

 − 0.44

0.20

0.024

 − 0.22

0.10

0.024

  

rs79333046

A

G

Intron

0.213

 − 0.07

0.02

1.21 × 10−3

 − 0.07

0.06

0.207

 − 0.05

0.03

0.088

  

rs76635931

G

T

Intron

0.014

0.09

0.07

0.187

 − 1.08

1.13

0.335

NA

NA

NA

  

rs111863451

G

T

Intron

0.027

 − 0.02

0.05

0.685

0.80

0.40

0.045

0.40

0.20

0.046

  

rs145333058

T

C

Intron

0.015

0.02

0.07

0.716

 − 0.54

0.80

0.495

 − 0.27

0.40

0.495

  

rs146937293

C

T

Intron

0.043

0.01

0.04

0.770

0.09

0.23

0.709

0.04

0.12

0.707

  

rs77328500

G

A

Intron

0.077

 − 0.02

0.03

0.442

0.03

0.15

0.860

0.01

0.08

0.879

  

rs74653915

C

T

Intron

0.016

 − 0.11

0.06

0.103

0.02

0.80

0.980

0.01

0.40

0.984

GABRA5

15

rs78575803

A

G

Intron

0.101

0.02

0.03

0.498

0.11

0.10

0.297

0.06

0.05

0.287

  

rs7165524

T

C

Intron

0.270

 − 0.02

0.02

0.311

 − 0.02

0.04

0.721

 − 0.01

0.02

0.573

  

rs80063633

A

C

Intron

0.151

0.00

0.02

0.949

0.15

0.07

0.045

0.07

0.04

0.049

  

rs140148185

A

G

Intron

0.090

 − 0.01

0.03

0.809

0.39

0.13

2.73 × 10−3

0.19

0.06

3.05 × 10−3

  

rs146013014

G

A

Intron

0.026

0.07

0.05

0.182

0.55

0.40

0.163

0.28

0.20

0.161

  

rs189790076

C

G

Intron

0.016

0.06

0.06

0.316

1.84

0.56

1.05 × 10−3

0.92

0.28

1.04 × 10−3

  

rs140319999

T

C

Intron

0.018

0.10

0.06

0.103

 − 0.17

0.80

0.827

 − 0.09

0.40

0.831

  

rs34560927

T

C

Intron

0.372

0.00

0.02

0.988

0.06

0.03

0.091

0.02

0.02

0.174

GABRG3

15

rs34984550

G

C

Intron

0.024

0.00

0.05

0.941

 − 0.18

0.56

0.752

 − 0.09

0.28

0.752

  

rs140670

A

T

Intron

0.293

0.01

0.02

0.664

 − 0.03

0.04

0.455

 − 0.01

0.02

0.586

  

rs147619342

T

C

Intron

0.017

 − 0.08

0.06

0.208

 − 1.45

0.50

4.02 × 10−3

 − 0.72

0.25

3.97 × 10−3

  

rs12903002

T

C

Intron

0.088

0.02

0.03

0.490

0.01

0.13

0.921

0.01

0.07

0.901

  

rs1017364

G

A

Intron

0.266

0.03

0.02

0.217

 − 0.01

0.04

0.813

0.00

0.02

0.946

  

rs150722146

A

G

Intron

0.026

 − 0.05

0.05

0.282

 − 0.29

0.56

0.604

 − 0.15

0.28

0.601

  

rs138047237

A

G

Intron

0.013

0.06

0.07

0.384

1.30

0.80

0.103

0.65

0.40

0.103

  

rs734254

A

G

Intron

0.034

 − 0.11

0.05

0.018

 − 0.33

0.34

0.325

 − 0.17

0.17

0.316

  

rs12593313

G

C

Intron

0.022

0.00

0.06

0.989

 − 0.01

0.43

0.990

0.00

0.21

0.990

  

rs140853604

T

C

Intron

0.031

 − 0.01

0.05

0.789

0.32

0.37

0.387

0.16

0.19

0.389

  

rs7173587

T

C

Intron

0.157

 − 0.06

0.02

0.023

0.08

0.07

0.288

0.03

0.04

0.419

  

rs143682098

G

A

Intron

0.053

 − 0.02

0.04

0.679

 − 0.12

0.25

0.645

 − 0.06

0.13

0.641

  

rs17739682

G

A

Intron

0.072

0.02

0.03

0.620

0.12

0.17

0.489

0.06

0.08

0.483

  

rs144369966

C

T

Intron

0.018

0.06

0.06

0.316

 − 0.29

0.65

0.653

 − 0.14

0.32

0.656

  

rs67338000

A

G

Intron

0.449

 − 0.04

0.02

0.068

0.00

0.03

0.859

 − 0.01

0.02

0.401

  

rs8028000

C

T

Intron

0.014

 − 0.14

0.07

0.041

 − 1.64

0.80

0.039

 − 0.82

0.40

0.039

  

rs61507711

T

C

Intron

0.097

0.02

0.03

0.582

0.10

0.12

0.384

0.05

0.06

0.376

  

rs9302372

A

G

Intron

0.042

0.02

0.04

0.670

 − 0.08

0.23

0.740

 − 0.04

0.12

0.745

  

rs4555109

T

G

Intron

0.222

0.04

0.02

0.104

0.01

0.05

0.825

0.01

0.03

0.624

  

rs149403614

A

G

Intron

0.035

0.00

0.04

0.994

0.05

0.40

0.894

0.03

0.20

0.894

  

rs28399529

G

A

3′ UTR

0.022

0.00

0.06

0.965

 − 0.25

0.65

0.705

 − 0.12

0.33

0.705

  1. Analysis was obtained after adjustment for covariates, including age, gender, physical activity, coffee consumption, tea consumption, smoking, alcohol consumption, body mass index (BMI), and status of chronic disorders
  2. P values < 0.05 represent the significant values and are shown in bold
  3. A1 minor allele, A2 major allele, GABAA gamma-aminobutyric acid type A, Beta Beta coefficients, Chr chromosome, MAF minor allele frequency, NA not available, SE standard error