Table 1 Characteristics of patients with acute myeloid leukemia (AML)
Characteristics | Patients (N,%) | (N,%) | P | |
|---|---|---|---|---|
Training group (n = 92) | Validation group (n = 38) | |||
Sex | 0.948 | |||
Female | 61 (46.9) | 43 (46.7) | 18 (47.4) | |
Male | 69 (53.1) | 49 (53.3) | 20 (52.6) | |
Age,years | 0.123 | |||
≤ 55 | 65 (50.0) | 50 (54.3) | 15 (39.5) | |
> 55 | 65 (50.0) | 42 (45.7) | 23 (60.5) | |
FAB subtype | 0.706 | |||
M0 | 12 (9.2) | 11 (12.0) | 1 (2.6) | |
M1 | 31 (23.8) | 20 (21.7) | 11 (28.9) | |
M2 | 32 (24.6) | 21 (22.8) | 11 (28.9) | |
M3 | 13 (10.0) | 10 (10.8) | 3 (7.9) | |
M4 | 27 (20.8) | 19 (20.7) | 8 (21.1) | |
M5 | 12 (9.2) | 8 (8.7) | 4 (10.6) | |
M6 | 2 (1.6) | 2 (2.2) | 0 (0) | |
M7 | 1 (0.8) | 1 (1.1) | 0 (0) | |
Cytogenetics risk category | ||||
Favorable | 29 (22.3) | 24 (26.1) | 5 (13.2) | 0.349 |
Intermediate/Normal | 72 (55.4) | 50 (54.3) | 22 (57.9) | |
Poor | 27 (20.8) | 17 (18.5) | 10 (26.3) | |
Unknow | 2 (1.5) | 1 (1.1) | 1 (2.6) | |
FLT3 mutation | 0.937 | |||
Positive | 33 (25.4) | 24 (26.1) | 9 (23.7) | |
Negative | 93 (71.5) | 65 (70.6) | 28 (73.7) | |
Unknow | 4 (3.1) | 3 (3.3) | 1 (2.6) | |
IDH1 R132 | 0.704 | |||
Positive | 13 (10.0) | 10 (10.9) | 3 (7.9) | |
Negative | 116 (89.2) | 81 (88.0) | 35 (92.1) | |
Unknow | 1 (0.8) | 1 (1.1) | 0 (0) | |
IDH1 R140 | 0.337 | |||
Positive | 11 (8.5) | 6 (6.5) | 5 (13.5) | |
Negative | 116 (89.9) | 85 (92.4) | 31 (83.8) | |
Unknow | 2 (1.6) | 1 (1.1) | 1 (2.7) | |
NPMc | 0.811 | |||
Positive | 31 (23.8) | 22 (23.9) | 9 (23.7) | |
Negative | 98 (75.4) | 69 (75.0) | 29 (76.3) | |
Unknow | 1 (0.8) | 1 (1.1) | 0 (0) | |
Follow-up state | 0.123 | |||
Alive | 51 (39.2) | 40 (43.5) | 11 (28.9) | |
Died | 79 (60.8) | 52 (56.5) | 27 (71.1) | |