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Fig. 3 | BMC Medical Genomics

Fig. 3

From: Identification and validation of pivotal genes related to age-related meniscus degeneration based on gene expression profiling analysis and in vivo and in vitro models detection

Fig. 3

The PPI network and Hub genes analysis. A PPI network of all DEGs (The red codes represent upregulated genes in the elderly, the blue codes represent downregulated genes in the elderly, and the size of the nodes represents the correlation between them). Hub gene networks obtained from the PPI network relying on B the Maximal Clique Centrality (MCC) algorithm, C the Maximum Neighborhood Component (MNC) algorithm, D the Degree algorithm, and E the Edge Percolated Component (EPC) algorithm of the Cytoscape plugin cytoHubba. F The Venn diagram showed the identified hub genes (RRM2, AURKB, CDK1, and TIMP1). G The heatmap of common hub genes identified by Metascape was colored by –log10 (P-value). PPI protein–protein interaction; DEGs differentially expressed genes; RRM2 ribonucleotide reductase regulatory subunit M2; AURKB aurora kinase B; CDK1 cyclin dependent kinase 1; TIMP1 tissue inhibitor of metalloproteinases 1

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BMC Medical Genomics

ISSN: 1755-8794

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