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Fig. 4 | BMC Medical Genomics

Fig. 4

From: Identification and validation of pivotal genes related to age-related meniscus degeneration based on gene expression profiling analysis and in vivo and in vitro models detection

Fig. 4

Network construction of lncRNA-miRNA-mRNA. A The mRNA-miRNA network was constructed by using the miRWalk website (The five miRNAs most associated with the common hub gene are highlighted in light blue). B Meaningful signal pathways about the 5 miRNAs by utilizing the DIANA-miRPath. C The lncRNA–miRNA–mRNA regulatory network (The orange nodes represent the lncRNAs, the yellow nodes represent key miRNAs, and the red nodes represent the hub genes). RRM2 ribonucleotide reductase regulatory subunit M2; AURKB aurora kinase B; CDK1 cyclin dependent kinase 1; TIMP1 tissue inhibitor of metalloproteinases 1

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BMC Medical Genomics

ISSN: 1755-8794

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