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Fig. 5 | BMC Medical Genomics

Fig. 5

From: Identification and validation of pivotal genes related to age-related meniscus degeneration based on gene expression profiling analysis and in vivo and in vitro models detection

Fig. 5

The expression levels of Hub genes in the meniscus tissues. A SafraninO-Fast green and Toloniumchloride Blue staining results of meniscus in 18-month-old mice (aging) and 3-month-old mice (young). Scale bar: 250 μm. Scale bar (enlarged): 100 μm. B Hub genes immunochemical staining of meniscus in young mice and older mice. Scale bar: 100 μm. C Quantification of Hub genes immunostaining (mean optical density). D Immunostaining of Hub genes in young and gerontic human menisci. Scale bar: 100 μm. E Quantification of Hub genes immunostaining (mean optical density). F The mRNA expression levels of Hub genes in human and mouse menisci, respectively. We normalized the gene expression levels to GAPDH. RRM2 ribonucleotide reductase regulatory subunit M2; AURKB aurora kinase B; CDK1 cyclin dependent kinase 1; TIMP1 tissue inhibitor of metalloproteinases 1; GAPDH Glyceraldehyde 3-phosphate dehydrogenase. n = 6 per group, mean ± S.E.M., *P < 0.05 compared with the young group

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BMC Medical Genomics

ISSN: 1755-8794

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