Fig. 1.

The flow charts of targeted linked-read sequencing and proband-based indirect phasing. a Parental genotypes and haplotype determination, prediction of fetal haplotype and noninvasive prenatal diagnosis of monogenic diseases using the targeted linked-read sequencing method. b Parental and proband's genotype and haplotype determination, prediction of fetal haplotype and noninvasive prenatal diagnosis of monogenic diseases using the proband-based indirect phasing method