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Table 3 Association of gene dosage of ANRIL tag SNPs with CAD severity

From: Genetic and epigenetic associations of ANRIL with coronary artery disease and risk factors

SNP Genotype/p-value CAD, n (%) Criminal Vessels, n (%) Gensini scores
Yes No Multi-VD 1-VD n Mean ± SD
rs1004638 TT 27 (28.42) 68 (71.58) 15 (55.56) 12 (44.44) 27 37.17 ± 34.28
AT 206 (49.76) 208 (50.24) 131 (63.59) 75 (36.41) 205 37.36 ± 32.62
AA 268 (54.36) 225 (45.64) 183 (68.28) 85 (31.72) 268 41.93 ± 34.08
P < 0.001 0.296 0.313
rs1333048 AA 104 (42.45) 141 (57.55) 63 (60.58) 41 (39.42) 104 34.47 ± 30.52
AC 249 (49.02) 259 (50.98) 158 (63.45) 91 (36.55) 248 36.69 ± 32.78
CC 147 (60.25) 97 (39.75) 107 (72.79) 40 (27.21) 147 49.01 ± 35.16
P < 0.001 0.027 < 0.001
rs1333050 CC 101 (44.89) 124 (55.11) 66 (65.35) 35 (34.65) 101 36.96 ± 32.39
CT 259 (49.43) 265 (50.57) 162 (62.55) 97 (37.45) 258 36.11 ± 31.51
TT 142 (56.57) 109 (43.43) 102 (71.83) 40 (28.17) 142 48.61 ± 36.24
P 0.034 0.172 0.001
  1. CAD: coronary artery disease; Multi-VD: multi-vessel disease; 1-VD: 1-vessel disease. SD: standard deviation