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Table 4 The association analysis for each genetic model

From: Association of MTHFR C677T variant genotype with serum folate and Vit B12 in Iranian patients with colorectal cancer or adenomatous polyps

Model Genotype Control (%) Case (%) OR (CI95%) P-value ORa (CI95%) P-valuea
Codominant C/C 305 (61%) 215 (51.3%) Ref   Ref  
C/T 161 (32.2%) 112 (26.7%) 0.99 (0.73–1.33) 0.931 0.95 (0.70–1.29) 0.74361
T/T 34 (6.8%) 92 (22%) 3.84 (2.50–5.90) 9.01e−10 3.68 (2.35–5.75) 1.20e−08
Dominant C/C 305 (61%) 215 (51.3%) Ref   Ref  
C/T–T/T 195 (39%) 204 (48.7%) 1.48 (1.14–1.93) 0.00322 1.42 (1.08–1.87) 0.0114
Recessive C/C–C/T 466 (93.2%) 327 (78%) Ref   Ref  
T/T 34 (6.8%) 92 (22%) 3.86 (2.54–5.86) 2.48e−10 3.74 (2.42–5.78) 2.72e−09
Over dominant C/C–T/T 339 (67.8%) 307 (73.3%) Ref   Ref  
C/T 161 (32.2%) 112 (26.7%) 0.77 (0.58–1.02) 0.071 0.74 (0.55–1.00) 0.0528
log-Additive 0, 1, 2 500 (54.4%) 419 (45.6%) 1.62 (1.35–1.95) 1.842e−07 1.58 (1.30–1.91) 2.353e−06
  1. Bold indicates a p-value less than 0.05 is statistically significant
  2. aAdjusted for age, sex, and addiction