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Table 4 The association analysis for each genetic model

From: Association of MTHFR C677T variant genotype with serum folate and Vit B12 in Iranian patients with colorectal cancer or adenomatous polyps

Model

Genotype

Control (%)

Case (%)

OR (CI95%)

P-value

ORa (CI95%)

P-valuea

Codominant

C/C

305 (61%)

215 (51.3%)

Ref

 

Ref

 

C/T

161 (32.2%)

112 (26.7%)

0.99 (0.73–1.33)

0.931

0.95 (0.70–1.29)

0.74361

T/T

34 (6.8%)

92 (22%)

3.84 (2.50–5.90)

9.01e−10

3.68 (2.35–5.75)

1.20e−08

Dominant

C/C

305 (61%)

215 (51.3%)

Ref

 

Ref

 

C/T–T/T

195 (39%)

204 (48.7%)

1.48 (1.14–1.93)

0.00322

1.42 (1.08–1.87)

0.0114

Recessive

C/C–C/T

466 (93.2%)

327 (78%)

Ref

 

Ref

 

T/T

34 (6.8%)

92 (22%)

3.86 (2.54–5.86)

2.48e−10

3.74 (2.42–5.78)

2.72e−09

Over dominant

C/C–T/T

339 (67.8%)

307 (73.3%)

Ref

 

Ref

 

C/T

161 (32.2%)

112 (26.7%)

0.77 (0.58–1.02)

0.071

0.74 (0.55–1.00)

0.0528

log-Additive

0, 1, 2

500 (54.4%)

419 (45.6%)

1.62 (1.35–1.95)

1.842e−07

1.58 (1.30–1.91)

2.353e−06

  1. Bold indicates a p-value less than 0.05 is statistically significant
  2. aAdjusted for age, sex, and addiction