|
Location
|
Model
|
Genotype
|
Control (%)
|
Case (%)
|
OR (95%CI)
|
P-value
|
ORa
|
P-valuea
|
|---|
|
Colon
|
Codominant
|
C/C
|
305 (61%)
|
105 (51%)
|
Ref
|
2.17e−05
|
Ref
|
5.30e−05
|
|
C/T
|
161 (32.2%)
|
62 (30.1%)
|
1.12 (0.77–1.62)
| |
1.1 (0.76–1.6)
| |
|
T/T
|
34 (6.8%)
|
39 (18.9%)
|
3.33 (2–5.55)
| |
3.27 (1.93–5.54)
| |
|
Dominant
|
C/C
|
305 (61%)
|
105 (51%)
|
Ref
|
0.014404
|
Ref
|
0.021843
|
|
C/T–T/T
|
195 (39%)
|
101 (49%)
|
1.5 (1.08–2.09)
| |
1.48 (1.06–2.07)
| |
|
Recessive
|
C/C–C/T
|
466 (93.2%)
|
167 (81.1%)
|
Ref
|
4.31e−06
|
Ref
|
1.04e−05
|
|
T/T
|
34 (6.8%)
|
39 (18.9%)
|
3.2 (1.96–5.24)
| |
3.16 (1.9–5.26)
| |
|
Over dominant
|
C/C–T/T
|
339 (67.8%)
|
144 (69.9%)
|
Ref
|
0.583813
|
Ref
|
0.558616
|
|
C/T
|
161 (32.2%)
|
62 (30.1%)
|
0.91 (0.64–1.29)
| |
0.9 (0.63–1.29)
| |
|
log-Additive
|
0, 1, 2
|
500 (70.8%)
|
206 (29.2%)
|
1.6 (1.26–2.02)
|
9.44e−05
|
1.57 (1.24–2)
|
0.000217
|
|
Rectosigmoid
|
Codominant
|
C/C
|
305 (61%)
|
110 (51.6%)
|
Ref
|
7.24e−10
|
Ref
|
5.88e−09
|
|
C/T
|
161 (32.2%)
|
50 (23.5%)
|
0.86 (0.59–1.27)
| |
0.79 (0.53–1.18)
| |
|
T/T
|
34 (6.8%)
|
53 (24.9%)
|
4.32 (2.67–7)
| |
4.16 (2.48–6.96)
| |
|
Dominant
|
C/C
|
305 (61%)
|
110 (51.6%)
|
Ref
|
0.020807
|
Ref
|
0.080438
|
|
C/T–T/T
|
195 (39%)
|
103 (48.4%)
|
1.46 (1.06–2.02)
| |
1.35 (0.96–1.9)
| |
|
Recessive
|
C/C–C/T
|
466 (93.2%)
|
160 (75.1%)
|
Ref
|
1.17e−10
|
Ref
|
1.49e−09
|
|
T/T
|
34 (6.8%)
|
53 (24.9%)
|
4.54 (2.85–7.24)
| |
4.5 (2.73–7.41)
| |
|
Over dominant
|
C/C–T/T
|
339 (67.8%)
|
163 (76.5%)
|
Ref
|
0.017874
|
Ref
|
0.006936
|
|
C/T
|
161 (32.2%)
|
50 (23.5%)
|
0.65 (0.45–0.93)
| |
0.59 (0.4–0.87)
| |
|
log-Additive
|
0, 1, 2
|
500 (70.1%)
|
213 (29.9%)
|
1.71 (1.37–2.14)
|
2.54e−06
|
1.64 (1.29–2.07)
|
3.75e−05
|
- Bold indicates a p-value less than 0.05 is statistically significant
- aAdjusted for age, sex, and addiction
