Skip to main content

Table 5 The association analysis stratified for tumor location

From: Association of MTHFR C677T variant genotype with serum folate and Vit B12 in Iranian patients with colorectal cancer or adenomatous polyps

Location Model Genotype Control (%) Case (%) OR (95%CI) P-value ORa P-valuea
Colon Codominant C/C 305 (61%) 105 (51%) Ref 2.17e−05 Ref 5.30e−05
C/T 161 (32.2%) 62 (30.1%) 1.12 (0.77–1.62)   1.1 (0.76–1.6)  
T/T 34 (6.8%) 39 (18.9%) 3.33 (2–5.55)   3.27 (1.93–5.54)  
Dominant C/C 305 (61%) 105 (51%) Ref 0.014404 Ref 0.021843
C/T–T/T 195 (39%) 101 (49%) 1.5 (1.08–2.09)   1.48 (1.06–2.07)  
Recessive C/C–C/T 466 (93.2%) 167 (81.1%) Ref 4.31e−06 Ref 1.04e−05
T/T 34 (6.8%) 39 (18.9%) 3.2 (1.96–5.24)   3.16 (1.9–5.26)  
Over dominant C/C–T/T 339 (67.8%) 144 (69.9%) Ref 0.583813 Ref 0.558616
C/T 161 (32.2%) 62 (30.1%) 0.91 (0.64–1.29)   0.9 (0.63–1.29)  
log-Additive 0, 1, 2 500 (70.8%) 206 (29.2%) 1.6 (1.26–2.02) 9.44e−05 1.57 (1.24–2) 0.000217
Rectosigmoid Codominant C/C 305 (61%) 110 (51.6%) Ref 7.24e−10 Ref 5.88e−09
C/T 161 (32.2%) 50 (23.5%) 0.86 (0.59–1.27)   0.79 (0.53–1.18)  
T/T 34 (6.8%) 53 (24.9%) 4.32 (2.67–7)   4.16 (2.48–6.96)  
Dominant C/C 305 (61%) 110 (51.6%) Ref 0.020807 Ref 0.080438
C/T–T/T 195 (39%) 103 (48.4%) 1.46 (1.06–2.02)   1.35 (0.96–1.9)  
Recessive C/C–C/T 466 (93.2%) 160 (75.1%) Ref 1.17e−10 Ref 1.49e−09
T/T 34 (6.8%) 53 (24.9%) 4.54 (2.85–7.24)   4.5 (2.73–7.41)  
Over dominant C/C–T/T 339 (67.8%) 163 (76.5%) Ref 0.017874 Ref 0.006936
C/T 161 (32.2%) 50 (23.5%) 0.65 (0.45–0.93)   0.59 (0.4–0.87)  
log-Additive 0, 1, 2 500 (70.1%) 213 (29.9%) 1.71 (1.37–2.14) 2.54e−06 1.64 (1.29–2.07) 3.75e−05
  1. Bold indicates a p-value less than 0.05 is statistically significant
  2. aAdjusted for age, sex, and addiction