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Table 3 Analysis of the association between susceptibility of type 2 diabetes and single nucleotide polymorphism of CTNNA3

From: CTNNA3 genetic polymorphism may be a new genetic signal of type 2 diabetes in the Chinese Han population: a case control study

SNP ID Model Genotype Case Control Adjusted by age and gender
OR (95% CI) p
rs10822745 Allele C 430 (42.91%) 417 (41.70%) 1.05 (0.88–1.26) 0.582
   T 572 (57.09%) 583 (58.30%) 1.00  
  Genotype CC 87 (17.4%) 84 (16.8%) 1.10 (0.76–1.59) 0.631
   CT 256 (51.1%) 249 (49.8%) 1.09 (0.82–1.44) 0.558
   TT 158 (31.5%) 167 (33.4%) 1.00  
  Dominant CC-CT 343 (68.5%) 333 (66.6%) 1.09 (0.84–1.42) 0.528
   TT 158 (31.5%) 167 (33.4%) 1.00  
  Recessive CC 87 (17.4%) 84 (16.8%) 1.04 (0.75–1.45) 0.811
   CT-TT 414 (82.6%) 416 (83.2%) 1.00  
  Log-additive – – – 1.05 (0.88–1.26) 0.575
rs7920624 Allele A 485 (48.79%) 498 (49.80%) 0.96 (0.81–1.15) 0.653
  T 509 (51.21%) 502 (50.20%) 1.00  
  Genotype AA 110 (22.1%) 123 (24.6%) 0.91 (0.64–1.31) 0.623
   AT 265 (53.3%) 252 (50.4%) 1.08 (0.80–1.46) 0.629
   TT 122 (24.6%) 125 (25%) 1.00  
  Dominant AA-AT 375 (75.5%) 375 (75%) 1.02 (0.77–1.37) 0.872
  TT 122 (24.6%) 125 (25%) 1.00  
  Recessive AA 110 (22.1%) 123 (24.6%) 0.87 (0.65–1.17) 0.349
  AT-TT 387 (77.9%) 377 (75.4%) 1.00  
  Log-additive – – – 0.96 (0.80–1.15) 0.637
rs2441727 Allele A 182 (18.16%) 202 (20.45%) 0.86 (0.69–1.08) 0.197
  G 820 (81.84%) 786 (79.55%) 1.00  
  Genotype AA 17 (3.4%) 17 (3.4%) 0.91 (0.46–1.83) 0.802
   AG 148 (29.5%) 168 (34%) 0.81 (0.62–1.06) 0.128
   GG 336 (67.1%) 309 (62.5%) 1.00  
  Dominant AA-AG 165 (32.9%) 185 (37.5%) 0.82 (0.63–1.07) 0.137
  GG 336 (67.1%) 309 (62.5%) 1.00  
  Recessive AA 17 (3.4%) 17 (3.4%) 0.98 (0.49–1.95) 0.955
  AG-GG 484 (96.6%) 477 (96.6%) 1.00  
  Log-additive – – – 0.86 (0.69–1.08) 0.192
rs7914287 Allele T 355 (35.50%) 284 (29.22%) 1.33 (1.10–1.61) 0.003*
  C 645 (64.50%) 688 (70.78%) 1.00  
  Genotype TT 68 (13.6%) 34 (7%) 2.21 (1.41–3.47) 0.001*
   TC 219 (43.8%) 216 (44.4%) 1.12 (0.86–1.46) 0.389
   CC 213 (42.6%) 236 (48.6%) 1.00  
  Dominant TT-TC 287 (57.4%) 250 (51.4%) 1.27 (0.99–1.63) 0.062
  CC 213 (42.6%) 236 (48.6%) 1.00  
  Recessive TT 68 (13.6%) 34 (7%) 2.09 (1.36–3.22) 0.001*
  TC-CC 432 (86.4%) 452 (93%) 1.00  
  Log-additive – – – 1.34 (1.10–1.62) 0.003*
  1. SNP, Single nucleotide polymorphisms; OR, odds ratio; CI, Confidence interval
  2. p < 0.05, bold text and '*' indicate statistical significance
  3. “–” indicates Log-additive model
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BMC Medical Genomics

ISSN: 1755-8794

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