Table 4 The SNPs of CTNNA3 associated with susceptibility of type 2 diabetes in the subgroup tests (age and gender)
SNP ID | Model | Genotype | Age, years | Gender | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
OR (95% CI) | p | OR (95% CI) | P | OR (95% CI) | p | OR (95% CI) | p | |||
≤ 60 (N = 500) | > 60 (N = 502) | Female (N = 284) | Male (N = 718) | |||||||
rs10822745 | Allele | C | 1.03 (0.80–1.32) | 0.844 | 1.07 (0.83–1.38) | 0.587 | 1.09 (0.78–1.53) | 0.600 | 1.04 (0.84–1.28) | 0.749 |
T | 1.00 | 1.00 | 1.00 | 1.00 | ||||||
Genotype | CC | 1.09 (0.65–1.85) | 0.739 | 1.05 (0.61–1.79) | 0.872 | 1.20 (0.61–2.36) | 0.601 | 1.05 (0.68–1.64) | 0.816 | |
CT | 0.91 (0.61–1.36) | 0.660 | 1.21 (0.81–1.81) | 0.348 | 1.08 (0.64–1.82) | 0.775 | 1.09 (0.78–1.52) | 0.613 | ||
TT | 1.00 | 1.00 | 1.00 | 1.00 | ||||||
Dominant | CC-CT | 0.96 (0.65–1.40) | 0.819 | 1.17 (0.8–1.71) | 0.426 | 1.11 (0.68–1.82) | 0.675 | 1.08 (0.79–1.48) | 0.630 | |
TT | 1.00 | 1.00 | 1.00 | 1.00 | ||||||
Recessive | CC | 1.16 (0.73–1.84) | 0.541 | 0.93 (0.58–1.51) | 0.771 | 1.15 (0.62–2.11) | 0.659 | 1.00 (0.68–1.48) | 0.999 | |
CT-TT | 1.00 | 1.00 | 1.00 | 1.00 | ||||||
Log-additive | – | 1.02 (0.79–1.32) | 0.854 | 1.05 (0.81–1.37) | 0.699 | 1.09 (0.78–1.52) | 0.601 | 1.04 (0.84–1.29) | 0.742 | |
rs7920624 | Allele | A | 1.13 (0.88–1.45) | 0.329 | 1.05 (0.82–1.35) | 0.700 | 0.95 (0.68–1.31) | 0.737 | 0.97 (0.79–1.19) | 0.749 |
T | 1.00 | 1.00 | 1.00 | 1.00 | ||||||
Genotype | AA | 1.28 (0.76–2.14) | 0.350 | 1.09 (0.65–1.83) | 0.745 | 0.89 (0.46–1.73) | 0.727 | 0.93 (0.60–1.42) | 0.720 | |
AT | 1.02 (0.65–1.59) | 0.949 | 1.47 (0.94–2.29) | 0.092 | 1.00 (0.57–1.76) | 1.000 | 1.11 (0.78–1.59) | 0.567 | ||
TT | 1.00 | 1.00 | 1.00 | 1.00 | ||||||
Dominant | AA-AT | 1.09 (0.72–1.67) | 0.679 | 1.33 (0.87–2.03) | 0.183 | 0.96 (0.57–1.64) | 0.890 | 1.05 (0.75–1.48) | 0.779 | |
TT | 1.00 | 1.00 | 1.00 | 1.00 | ||||||
Recessive | AA | 1.27 (0.84–1.90) | 0.259 | 0.84 (0.55–1.28) | 0.411 | 0.89 (0.51–1.54) | 0.673 | 0.86 (0.61–1.22) | 0.399 | |
AT-TT | 1.00 | 1.00 | 1.00 | 1.00 | ||||||
Log-additive | – | 1.14 (0.88–1.47) | 0.336 | 1.04 (0.81–1.35) | 0.755 | 0.94 (0.68–1.32) | 0.733 | 0.96 (0.78–1.19) | 0.733 | |
rs2441727 | Allele | A | 0.98 (0.71–1.35) | 0.887 | 0.78 (0.58–1.07) | 0.122 | 0.89 (0.60–1.33) | 0.581 | 0.85 (0.65–1.11) | 0.238 |
G | 1.00 | 1.00 | 1.00 | 1.00 | ||||||
Genotype | AA | 0.46 (0.11–1.88) | 0.281 | 0.73 (0.49–1.67) | 0.748 | 0.95 (0.36–2.03) | 0.933 | 0.82 (0.33–2.06) | 0.677 | |
AG | 0.86 (0.43–1.26) | 0.757 | 0.58 (0.39–0.87) | 0.008* | 0.80 (0.48–1.31) | 0.371 | 0.82 (0.59–1.13) | 0.218 | ||
GG | 1.00 | 1.00 | 1.00 | 1.00 | ||||||
Dominant | AA-AG | 0.84 (0.70–1.48) | 0.931 | 0.64 (0.44–0.93) | 0.021* | 0.83 (0.51–1.33) | 0.433 | 0.82 (0.60–1.12) | 0.206 | |
GG | 1.00 | 1.00 | 1.00 | 1.00 | ||||||
Recessive | AA | 0.45 (0.11–1.84) | 0.267 | 0.57 (0.60–0.76) | 0.455 | 0.94 (0.40–1.23) | 0.812 | 0.88 (0.35–2.19) | 0.775 | |
AG-GG | 1.00 | 1.00 | 1.00 | 1.00 | ||||||
Log-additive | – | 0.96 (0.68–1.36) | 0.830 | 0.77 (0.57–1.05) | 0.103 | 0.89 (0.60–1.33) | 0.579 | 0.84 (0.64–1.11) | 0.228 | |
rs7914287 | Allele | T | 1.31 (1.00–1.72) | 0.052 | 1.37 (1.06–1.79) | 0.018* | 1.34 (0.94–1.90) | 0.107 | 2.33 (1.07–3.67) | 0.012* |
C | 1.00 | 1.00 | 1.00 | 1.00 | ||||||
Genotype | TT | 2.71 (1.36–5.42) | 0.057 | 2.22 (1.18–4.17) | 0.013* | 2.26 (0.97–5.22) | 0.058 | 2.20 (1.29–3.77) | 0.004* | |
TC | 0.99 (0.68–1.44) | 0.952 | 1.43 (0.97–2.11) | 0.070 | 1.11 (0.67–1.83) | 0.681 | 1.12 (0.82–1.54) | 0.461 | ||
CC | 1.00 | 1.00 | 1.00 | 1.00 | ||||||
Dominant | TT-TC | 1.18 (0.82–1.68) | 0.372 | 1.56 (1.08–2.25) | 0.019* | 1.27 (0.79–2.04) | 0.330 | 1.27 (0.95–1.71) | 0.113 | |
CC | 1.00 | 1.00 | 1.00 | 1.00 | ||||||
Recessive | TT | 2.73 (1.40–5.32) | 0.120 | 1.85 (1.02–3.35) | 0.044* | 2.14 (0.96–4.76) | 0.063 | 2.08 (1.24–3.49) | 0.005* | |
TC-CC | 1.00 | 1.00 | 1.00 | 1.00 | ||||||
Log-additive | – | 1.33 (1.01–1.75) | 0.064 | 1.47 (1.11–1.94) | 0.007* | 1.35 (0.94–1.93) | 0.106 | 2.33 (1.06–3.67) | 0.013* | |