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Table 4 The SNPs of CTNNA3 associated with susceptibility of type 2 diabetes in the subgroup tests (age and gender)

From: CTNNA3 genetic polymorphism may be a new genetic signal of type 2 diabetes in the Chinese Han population: a case control study

SNP ID Model Genotype Age, years Gender
OR (95% CI) p OR (95% CI) P OR (95% CI) p OR (95% CI) p
 ≤ 60 (N = 500)  > 60 (N = 502) Female (N = 284) Male (N = 718)
rs10822745 Allele C 1.03 (0.80–1.32) 0.844 1.07 (0.83–1.38) 0.587 1.09 (0.78–1.53) 0.600 1.04 (0.84–1.28) 0.749
   T 1.00   1.00   1.00   1.00  
  Genotype CC 1.09 (0.65–1.85) 0.739 1.05 (0.61–1.79) 0.872 1.20 (0.61–2.36) 0.601 1.05 (0.68–1.64) 0.816
   CT 0.91 (0.61–1.36) 0.660 1.21 (0.81–1.81) 0.348 1.08 (0.64–1.82) 0.775 1.09 (0.78–1.52) 0.613
   TT 1.00   1.00   1.00   1.00  
  Dominant CC-CT 0.96 (0.65–1.40) 0.819 1.17 (0.8–1.71) 0.426 1.11 (0.68–1.82) 0.675 1.08 (0.79–1.48) 0.630
   TT 1.00   1.00   1.00   1.00  
  Recessive CC 1.16 (0.73–1.84) 0.541 0.93 (0.58–1.51) 0.771 1.15 (0.62–2.11) 0.659 1.00 (0.68–1.48) 0.999
   CT-TT 1.00   1.00   1.00   1.00  
  Log-additive 1.02 (0.79–1.32) 0.854 1.05 (0.81–1.37) 0.699 1.09 (0.78–1.52) 0.601 1.04 (0.84–1.29) 0.742
rs7920624 Allele A 1.13 (0.88–1.45) 0.329 1.05 (0.82–1.35) 0.700 0.95 (0.68–1.31) 0.737 0.97 (0.79–1.19) 0.749
   T 1.00   1.00   1.00   1.00  
  Genotype AA 1.28 (0.76–2.14) 0.350 1.09 (0.65–1.83) 0.745 0.89 (0.46–1.73) 0.727 0.93 (0.60–1.42) 0.720
   AT 1.02 (0.65–1.59) 0.949 1.47 (0.94–2.29) 0.092 1.00 (0.57–1.76) 1.000 1.11 (0.78–1.59) 0.567
   TT 1.00   1.00   1.00   1.00  
  Dominant AA-AT 1.09 (0.72–1.67) 0.679 1.33 (0.87–2.03) 0.183 0.96 (0.57–1.64) 0.890 1.05 (0.75–1.48) 0.779
   TT 1.00   1.00   1.00   1.00  
  Recessive AA 1.27 (0.84–1.90) 0.259 0.84 (0.55–1.28) 0.411 0.89 (0.51–1.54) 0.673 0.86 (0.61–1.22) 0.399
   AT-TT 1.00   1.00   1.00   1.00  
  Log-additive 1.14 (0.88–1.47) 0.336 1.04 (0.81–1.35) 0.755 0.94 (0.68–1.32) 0.733 0.96 (0.78–1.19) 0.733
rs2441727 Allele A 0.98 (0.71–1.35) 0.887 0.78 (0.58–1.07) 0.122 0.89 (0.60–1.33) 0.581 0.85 (0.65–1.11) 0.238
   G 1.00   1.00   1.00   1.00  
  Genotype AA 0.46 (0.11–1.88) 0.281 0.73 (0.49–1.67) 0.748 0.95 (0.36–2.03) 0.933 0.82 (0.33–2.06) 0.677
   AG 0.86 (0.43–1.26) 0.757 0.58 (0.39–0.87) 0.008* 0.80 (0.48–1.31) 0.371 0.82 (0.59–1.13) 0.218
   GG 1.00   1.00   1.00   1.00  
  Dominant AA-AG 0.84 (0.70–1.48) 0.931 0.64 (0.44–0.93) 0.021* 0.83 (0.51–1.33) 0.433 0.82 (0.60–1.12) 0.206
   GG 1.00   1.00   1.00   1.00  
  Recessive AA 0.45 (0.11–1.84) 0.267 0.57 (0.60–0.76) 0.455 0.94 (0.40–1.23) 0.812 0.88 (0.35–2.19) 0.775
   AG-GG 1.00   1.00   1.00   1.00  
  Log-additive 0.96 (0.68–1.36) 0.830 0.77 (0.57–1.05) 0.103 0.89 (0.60–1.33) 0.579 0.84 (0.64–1.11) 0.228
rs7914287 Allele T 1.31 (1.00–1.72) 0.052 1.37 (1.06–1.79) 0.018* 1.34 (0.94–1.90) 0.107 2.33 (1.07–3.67) 0.012*
   C 1.00   1.00   1.00   1.00  
  Genotype TT 2.71 (1.36–5.42) 0.057 2.22 (1.18–4.17) 0.013* 2.26 (0.97–5.22) 0.058 2.20 (1.29–3.77) 0.004*
   TC 0.99 (0.68–1.44) 0.952 1.43 (0.97–2.11) 0.070 1.11 (0.67–1.83) 0.681 1.12 (0.82–1.54) 0.461
   CC 1.00   1.00   1.00   1.00  
  Dominant TT-TC 1.18 (0.82–1.68) 0.372 1.56 (1.08–2.25) 0.019* 1.27 (0.79–2.04) 0.330 1.27 (0.95–1.71) 0.113
   CC 1.00   1.00   1.00   1.00  
  Recessive TT 2.73 (1.40–5.32) 0.120 1.85 (1.02–3.35) 0.044* 2.14 (0.96–4.76) 0.063 2.08 (1.24–3.49) 0.005*
   TC-CC 1.00   1.00   1.00   1.00  
  Log-additive 1.33 (1.01–1.75) 0.064 1.47 (1.11–1.94) 0.007* 1.35 (0.94–1.93) 0.106 2.33 (1.06–3.67) 0.013*
  1. SNP, Single nucleotide polymorphisms; OR, odds ratio; CI, Confidence interval
  2. p < 0.05, bold text and '*' indicate statistical significance
  3. “–” indicates Log-additive model