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Table 7 The SNPs of CTNNA3 associated with susceptibility of type 2 diabetes in the subgroup tests (no retinal degeneration and course of type 2 diabetes)

From: CTNNA3 genetic polymorphism may be a new genetic signal of type 2 diabetes in the Chinese Han population: a case control study

SNP ID

Model

Genotype

No retinal degeneration

(No retinal degeneration in cases vs. ≤ control)

(N = 741)

Course of type 2 diabetes (> 10 vs. ≤ 10 years)

(N = 500)

OR (95% CI)

p

OR (95% CI)

p

rs10822745

Allele

C/T

1.07 (0.86–1.33)

0.552

0.74 (0.57–0.96)

0.022*

 

Homozygote

CC/TT

1.07 (0.66–1.72)

0.795

0.49 (0.28–0.88)

0.017*

 

Heterozygote

CT

1.30 (0.92–1.85)

0.139

0.83 (0.55–1.25)

0.368

 

Dominant

CC-CT/TT

1.24 (0.89–1.74)

0.204

0.73 (0.49–1.09)

0.120

 

Recessive

CC/CT-TT

0.90 (0.59–1.38)

0.631

0.55 (0.33–0.94)

0.027*

 

Log-additive

1.07 (0.86–1.35)

0.540

0.73 (0.55–0.96)

0.023*

rs7920624

Allele

A/T

0.95 (0.76–1.18)

0.647

1.33 (1.03–1.72)

0.030*

 

Homozygote

AA/TT

0.88 (0.55–1.41)

0.602

1.73 (1.00–3.01)

0.052

 

Heterozygote

AT

1.29 (0.88–1.90)

0.187

1.50 (0.94–2.40)

0.091

 

Dominant

AA-AT/TT

1.16 (0.80–1.67)

0.430

1.56 (1.00–2.45)

0.051

 

Recessive

AA/AT-TT

0.74 (0.50–1.08)

0.118

1.30 (0.84–2.03)

0.238

 

Log-additive

0.95 (0.76–1.19)

0.640

1.31 (1.00–1.73)

0.051

rs2441727

Allele

A/G

0.81 (0.61–1.08)

0.152

1.33 (1.03–1.72)

0.030*

 

Homozygote

AA/GG

0.56 (0.20–1.54)

0.261

0.61 (0.22–1.68)

0.336

 

Heterozygote

AG/GG

0.83 (0.59–1.16)

0.268

0.49 (0.32–0.76)

0.001*

 

Dominant

AA-AG/GG

0.80 (0.58–1.11)

0.188

0.50 (0.33–0.76)

0.001*

 

Recessive

AA/AG-GG

0.59 (0.22–1.64)

0.314

0.74 (0.27–2.04)

0.558

 

Log-additive

0.80 (0.60–1.08)

0.140

0.59 (0.41–0.84)

0.003*

rs7914287

Allele

T/C

1.31 (1.04–1.66)

0.022*

1.10 (0.85–1.44)

0.466

 

Homozygote

TT/CC

2.20 (1.29–3.75)

0.004*

1.23 (0.70–2.16)

0.479

 

Heterozygote

TC/CC

1.07 (0.77–1.49)

0.682

0.89 (0.60–1.34)

0.587

 

Dominant

TT-TC/CC

1.23 (0.90–1.68)

0.200

0.97 (0.66–1.41)

0.859

 

Recessive

TT/TC-CC

2.13 (1.28–3.54)

0.003*

1.30 (0.76–2.21)

0.334

 

Log-additive

1.32 (1.04–1.68)

0.021*

1.05 (0.80–1.37)

0.721

  1. OR, odds ratio; CI, confidence interval
  2. p < 0.05, bold text and '*' indicate statistical significance
  3. “–” indicates Log-additive model