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Table 7 The SNPs of CTNNA3 associated with susceptibility of type 2 diabetes in the subgroup tests (no retinal degeneration and course of type 2 diabetes)

From: CTNNA3 genetic polymorphism may be a new genetic signal of type 2 diabetes in the Chinese Han population: a case control study

SNP ID Model Genotype No retinal degeneration
(No retinal degeneration in cases vs. ≤ control)
(N = 741)
Course of type 2 diabetes (> 10 vs. ≤ 10 years)
(N = 500)
OR (95% CI) p OR (95% CI) p
rs10822745 Allele C/T 1.07 (0.86–1.33) 0.552 0.74 (0.57–0.96) 0.022*
  Homozygote CC/TT 1.07 (0.66–1.72) 0.795 0.49 (0.28–0.88) 0.017*
  Heterozygote CT 1.30 (0.92–1.85) 0.139 0.83 (0.55–1.25) 0.368
  Dominant CC-CT/TT 1.24 (0.89–1.74) 0.204 0.73 (0.49–1.09) 0.120
  Recessive CC/CT-TT 0.90 (0.59–1.38) 0.631 0.55 (0.33–0.94) 0.027*
  Log-additive 1.07 (0.86–1.35) 0.540 0.73 (0.55–0.96) 0.023*
rs7920624 Allele A/T 0.95 (0.76–1.18) 0.647 1.33 (1.03–1.72) 0.030*
  Homozygote AA/TT 0.88 (0.55–1.41) 0.602 1.73 (1.00–3.01) 0.052
  Heterozygote AT 1.29 (0.88–1.90) 0.187 1.50 (0.94–2.40) 0.091
  Dominant AA-AT/TT 1.16 (0.80–1.67) 0.430 1.56 (1.00–2.45) 0.051
  Recessive AA/AT-TT 0.74 (0.50–1.08) 0.118 1.30 (0.84–2.03) 0.238
  Log-additive 0.95 (0.76–1.19) 0.640 1.31 (1.00–1.73) 0.051
rs2441727 Allele A/G 0.81 (0.61–1.08) 0.152 1.33 (1.03–1.72) 0.030*
  Homozygote AA/GG 0.56 (0.20–1.54) 0.261 0.61 (0.22–1.68) 0.336
  Heterozygote AG/GG 0.83 (0.59–1.16) 0.268 0.49 (0.32–0.76) 0.001*
  Dominant AA-AG/GG 0.80 (0.58–1.11) 0.188 0.50 (0.33–0.76) 0.001*
  Recessive AA/AG-GG 0.59 (0.22–1.64) 0.314 0.74 (0.27–2.04) 0.558
  Log-additive 0.80 (0.60–1.08) 0.140 0.59 (0.41–0.84) 0.003*
rs7914287 Allele T/C 1.31 (1.04–1.66) 0.022* 1.10 (0.85–1.44) 0.466
  Homozygote TT/CC 2.20 (1.29–3.75) 0.004* 1.23 (0.70–2.16) 0.479
  Heterozygote TC/CC 1.07 (0.77–1.49) 0.682 0.89 (0.60–1.34) 0.587
  Dominant TT-TC/CC 1.23 (0.90–1.68) 0.200 0.97 (0.66–1.41) 0.859
  Recessive TT/TC-CC 2.13 (1.28–3.54) 0.003* 1.30 (0.76–2.21) 0.334
  Log-additive 1.32 (1.04–1.68) 0.021* 1.05 (0.80–1.37) 0.721
  1. OR, odds ratio; CI, confidence interval
  2. p < 0.05, bold text and '*' indicate statistical significance
  3. “–” indicates Log-additive model