Table 2 HPV16 E1 gene variations and amino acid substitutions
HPV16 E1 nucleotide variation | ||||||
|---|---|---|---|---|---|---|
Variant site | AA | As | Af | Number of variation samples | Variation frequency | Amino acid change |
(n = 109) | (%) | |||||
T98C | T | T | T | 3 | 2.75 | I33T |
T105C | T | T | T | 1 | 0.92 | D35D |
A117C | A | A | A | 3 | 2.75 | E39D |
A189C | A | A | A | 18 | 16.51 | E63D |
G195A | G | G | G | 3 | 2.75 | E65E |
G252A | G | G | G | 1 | 0.92 | Q84Q |
C256T | C | C | C | 1 | 0.92 | L86L |
T288C | T | T | T | 1 | 0.92 | S96S |
G299A | A | G | G | 5 | 4.59 | G100E |
A351C | A | A | A | 1 | 0.92 | K117N |
T377C | T | T | T | 1 | 0.92 | L126S |
T379C | T | T | T | 1 | 0.92 | F127L |
T519C | T | T | T | 1 | 0.92 | S173S |
A531T | A | A | A | 1 | 0.92 | G177G |
T557C | T | T | T | 31 | 28.44 | I186T |
C568T | C | C | C | 1 | 0.92 | P190S |
T583C | T | T | T | 1 | 0.92 | L195L |
T600C | T | T | T | 2 | 1.83 | T200T |
G651A | G | A | G | 62 | 56.88 | V217V |
T658A | A | T | T | 4 | 3.67 | S220T |
T723C | C | T | T | 3 | 2.75 | F241F |
T779C | T | T | T | 2 | 1.83 | L260S |
T784A | T | T | T | 1 | 0.92 | L262T |
A844T | A | A | A | 1 | 0.92 | K282* |
T939C | T | T | T | 1 | 0.92 | R313R |
A945G | A | A | A | 1 | 0.92 | T315T |
A969G | A | A | A | 1 | 0.92 | K323K |
A978G | G | G | G | 35 | 32.11 | I326M |
A1068C | A | A | A | 8 | 7.34 | E356D |
C1177T | T | C | T | 1 | 0.92 | L393L |
A1294C | A | A | A | 5 | 4.59 | R432R |
T1369C | T | T | T | 5 | 4.59 | L457L |
T1374G | T | T | T | 1 | 0.92 | T458T |
A1380G | A | A | A | 1 | 0.92 | L460L |
T1390C | C | T | T | 15 | 13.76 | L464L |
T1437C | T | T | T | 2 | 1.83 | A479A |
G1473A | G | A | G | 30 | 27.52 | M491I |
T1479C | C | T | T | 1 | 0.92 | F493F |
C1480T | T | C | T | 28 | 25.69 | L494L |
T1512G | T | T | T | 2 | 1.83 | S504S |
T1528C | T | T | T | 1 | 0.92 | L510L |
C1539T | C | C | C | 1 | 0.92 | Y531Y |
A1683G | A | A | A | 1 | 0.92 | P561P |
T1687C | T | T | T | 1 | 0.92 | L563L |
C1721T | C | C | C | 1 | 0.92 | S574F |
T1731G | T | T | T | 3 | 2.75 | P577P |
T1732A | T | T | T | 1 | 0.92 | Y578N |
C1901T | C | C | C | 1 | 0.92 | S634F |