Table 4 Genetic variation of genomic HPV16 E1 in case and control groups
Structural domain | Control groups (n = 66) | Case (n = 50) | P-values | Amino acid change | ||
|---|---|---|---|---|---|---|
Number of variation samples | Variation frequency (%) | Number of variation samples | Variation frequency (%) | |||
T98C | 0 | 0.0 | 2 | 4.0 | 0.101 | I33T |
A117C | 1 | 1.5 | 0 | 0.0 | 0.382 | E39D |
A189C | 3 | 4.5 | 7 | 14.0 | 0.072 | E63D |
G299A | 1 | 1.5 | 0 | 0.0 | 0.382 | G100E |
T557C | 6 | 9.1 | 8 | 16.0 | 0.258 | I186T |
T779C | 1 | 1.5 | 0 | 0.0 | 0.382 | L260S |
A978G | 14 | 21.2 | 19 | 38.0 | 0.047 | I326M |
A1030G | 0 | 0.0 | 1 | 2.0 | 0.249 | T344A |
A1068C | 3 | 4.5 | 6 | 12.0 | 0.137 | E356D |
G1171T | 0 | 0.0 | 1 | 2.0 | 0.249 | A391S |
G1473A | 7 | 10.6 | 22 | 44.0 | < 0.001 | M491I |
C568T | 0 | 0.0 | 1 | 2.0 | 0.249 | P190S |
A844T | 0 | 0.0 | 1 | 2.0 | 0.249 | K282* |
C1901G | 0 | 0.0 | 1 | 2.0 | 0.249 | S634C |
C1907A | 1 | 1.5 | 0 | 0.0 | 0.382 | P636Q |