Structural domain | Variant site | Control groups (n = 66) | Case (n = 50) | P-values | Amino acid change | ||
---|---|---|---|---|---|---|---|
Number of variation samples | Variation frequency (%) | Number of variation samples | Variation frequency (%) | ||||
Transcriptional activation domain | G1964A | 10 | 15.2 | 17 | 34.0 | 0.017 | D25N |
G2204A | 2 | 3.0 | 2 | 4.0 | 0.777 | A105T | |
C2295A | 11 | 16.7 | 19 | 38.0 | 0.009 | T135K | |
G2315A | 1 | 1.5 | 0 | 0.0 | 0.382 | E142D | |
G2385A | 7 | 10.6 | 16 | 32.0 | 0.004 | R165Q | |
T2394A | 0 | 0.0 | 1 | 2.0 | 0.249 | I168Y | |
T2410G | 5 | 7.6 | 7 | 14.0 | 0.261 | D173E | |
Hinge region | T2520C | 7 | 10.6 | 17 | 34.0 | 0.002 | I210T |
C2546T | 17 | 25.8 | 36 | 72.0 | < 0.001 | P219S | |
G2585A | 8 | 12.1 | 16 | 32.0 | 0.009 | E232K | |
G2621C | 1 | 1.5 | 0 | 0.0 | 0.382 | E244Q | |
A2636C | 0 | 0.0 | 1 | 2.0 | 0.249 | N249H | |
T2672C | 3 | 4.5 | 4 | 8.0 | 0.439 | S261P | |
T2703G | 0 | 0.0 | 2 | 4.0 | 0.101 | F271V | |
DNA binding domain | C2820A | 8 | 12.1 | 18 | 36.0 | 0.002 | T310K |
C2873T | 0 | 0.0 | 3 | 6.0 | 0.044 | H328Y | |
C2923A | 1 | 1.5 | 10 | 20.0 | 0.001 | D344E | |
C2934G | 0 | 0.0 | 2 | 4.0 | 0.101 | S348C |