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Table 1 Prevalence of gene mutations

From: Mutational signatures among young-onset testicular cancers

Gene 20–29 30–39  > 40 Total p-value
(20–29 vs. > 40)
p-value
(30–39 vs. > 40)
p-value (continuous age)
KIT 7 (12%) 8 (15%) 7 (33%) 22 (16%) 0.25 0.093 0.20
KRAS 4 (7%) 7 (13%) 3 (14%) 14 (10%) 0.65 0.99 0.55
NRAS 2 (3%) 2 (4%) 2 (10%) 6 (4%) 0.65 0.19 0.47
PIK3CD 1 (2%) 3 (6%) 1 (5%) 5 (4%) 0.62 0.84 0.66
PIK3CA 1 (2%) 2 (4%) 0 (0%) 3 (2%) NA NA 0.95
  1. Prevalence of somatic mutations in genes of interest among testicular tumors diagnosed at ages 20–29 (n = 59), 30–39 (n = 54), age 40 or older (n = 21), and at any age (n = 134). Entries are number (proportion) of cases in each age of onset group with each gene present. Differences in gene mutations by age at onset groups were tested using a logistic regression model * indicates statistical significance at a .05 level