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Table 4 Association of SNPs with HOMA-IR at 1–2 years postpartum in women with previous GDM

From: Association of single nucleotide polymorphisms with insulin secretion, insulin sensitivity, and diabetes in women with a history of gestational diabetes mellitus

SNP Locus Location CHR N EA B (SE) p value
rs2943641 IRS1 Intergenic 2 313 C 0.36 (0.18) 0.050
rs4675095 IRS1 Intron 2 355 A − 0.11 (0.55) 0.83
rs1801282 PPARG Coding – missense 3 307 C 0.29 (0.41) 0.48
rs35767 IGF1 Near Gene-5 12 305 G 0.02 (0.31) 0.94
  1. SNP = single nucleotide polymorphism, CHR = chromosome, N = number of women with successful genotyping, EA = effect allele, B = beta/effect size, SE = standard error; HOMA-IR was normalised using rank normal transformation