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Fig. 4 | BMC Medical Genomics

Fig. 4

From: Hub microRNAs and genes in the development of atrial fibrillation identified by weighted gene co-expression network analysis

Fig. 4

The identification of key modules by weighted gene co-expression network analysis. A Clustering dendrogram of samples in the dataset GSE28954. The red line in the dendrogram is the cut line for outlier detection, with samples cut by this line considered as outliers. B Clustering dendrogram of 9 AF and 18 non-AF samples. C Analysis of network topology for various soft-thresholding powers. D Clustering dendrogram of miRNAs, with dissimilarity based on topological overlap, together with assigned module colors. E The visualization of the co-expression modules using a heatmap. The degree of overlap increases with increasing intensity of yellow. F Eigengene adjacency heatmap of different co-expression modules. G The heatmap to show the correlation between module eigengenes and overall health status (healthy, valvular heart disease, coronary artery bypass graft, and AF). H The distribution of average expression significance across modules related to AF. I The scatter plot of module eigengenes in red module and blue module. AF, atrial fibrillation; miRNA, microRNA

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