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Fig. 1 | BMC Medical Genomics

Fig. 1

From: Rare and potentially pathogenic variants in hydroxycarboxylic acid receptor genes identified in breast cancer cases

Fig. 1

Rare missense variants in HCAR1 and HCAR3 detected in the AHCC. A Sanger sequencing comparisons of wildtype and mutant for HCAR1 variants p.P20A and p.L241F, and HCAR3 variant p.R187Q. B WebLogo amino acid conservation. The y-axis shows relative sequence conservation and the height of symbols in the stack show relative frequency for that position (HCAR1 was aligned with the following orthologues: Homo sapiens (Q9BXC0), Mus musculus (Q8C131), Canis lupus familiaris (B9UM26), Pan troglodytes (G2HJ56), Pongo pygmaeus (A0A4Y1JWL9), and Pan paniscus (A0A2R8ZEB9); HCAR3 was aligned with: Homo sapiens (P49019), Xenopus laevis (A0A1L8I0Z3), Pan troglodytes (H2RAM9), Pongo abelii (H2NJ01), Pan paniscus (A0A4Y1JWN7), and Pongo pygmaeus (A0A4Y1JWR4))

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