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Table 2 PSORT predictions of HCAR3 wildtype and mutant, p.Gln373Lysfs*82

From: Rare and potentially pathogenic variants in hydroxycarboxylic acid receptor genes identified in breast cancer cases

HCAR3 protein ER Membrane Retention Signals: NUCDISC: discrimination of nuclear localization signals Tripeptide SKL-motif Prenylation Motif k-NN (k-nearest neighbors algorithm)
Wildtype KKXX-like motif in the C-terminus: NONE content of basic residues: 9.8% peroxisomal targeting signal in the C-terminus: NONE CCIE 55.6%: endoplasmic reticulum 22.2% vacuolar 11.1% nuclear 11.1% Golgi
Mutant KKXX-like motif in the C-terminus: KMGK content of basic residues: 11.5% peroxisomal targeting signal in the C-terminus: GKL NONE 77.8%: endoplasmic reticulum 11.1% vacuolar 0.0% nuclear 11.1% Golgi