Skip to main content

Table 1 Univariable MR results of the effect of genetically predicted atherogenic lipid-related traits on COVID-19 risk

From: Estimating causal effects of atherogenic lipid-related traits on COVID-19 susceptibility and severity using a two-sample Mendelian randomization approach

Exposure traits Outcome traits N of SNVs IVW method MR-Egger regression method Weighted median method Weighted mode method Heterogeneity (IVW method)
OR (95% CI)
P-value
OR (95% CI)
P-value
Intercept (SE)
P-value
OR (95% CI)
P-value
OR (95% CI)
P-value
Cochran’s Q
P-value
Apo-B COVID-19 susceptibility 128 0.995 (0.93–1.07)
0.89
1.013 (0.91–1.12)
0.81
− 0.0009 (0.0019)
0.64
1.057 (0.93–1.19)
0.38
1.026 (0.93–1.14)
0.63
128.4
0.45
Apo-B COVID-19 hospitalization 126 0.995 (0.85–1.16)
0.94
0.909 (0.72–1.15)
0.43
0.0040 (0.0041)
0.33
0.902 (0.71–1.15)
0.41
0.881 (0.68–1.15)
0.35
125.7
0.47
Apo-B COVID-19 severity 130 1.033 (0.82–1.31)
0.79
0.933 (0.64–1.35)
0.71
0.0046 (0.0065)
0.48
0.935 (0.67–1.31)
0.70
0.979 (0.70–1.36)
0.90
172.0
0.007
LDL-C COVID-19 susceptibility 114 1.048 (0.96–1.14)
0.27
1.028 (0.89–1.18)
0.70
0.0008 (0.0023)
0.74
1.056 (0.93–1.20)
0.41
1.025 (0.90–1.17)
0.71
114.2
0.45
LDL-C COVID-19 hospitalization 113 0.986 (0.83–1.17)
0.86
0.853 (0.64–1.14)
0.28
0.0057 (0.0046)
0.22
0.892 (0.68–1.17)
0.41
0.889 (0.67–1.18)
0.42
108.5
0.58
LDL-C COVID-19 severity 115 1.034 (0.83–1.29)
0.77
0.806 (0.54–1.21)
0.30
0.0099 (0.0067)
0.14
0.882 (0.62–1.26)
0.49
0.949 (0.65–1.38)
0.79
127.1
0.19
TG COVID-19 susceptibility 208 1.065 (1.00–1.13)
0.045
1.101 (0.99–1.21)
0.052
− 0.0014 (0.0016)
0.36
1.099 (0.99–1.22)
0.07
1.079 (0.98–1.19)
0.13
235.9
0.08
TG COVID-19 hospitalization 205 1.174 (1.04–1.33)
0.012
1.275 (1.06–1.53)
0.010
− 0.0036 (0.0030)
0.23
1.167 (0.96–1.42)
0.12
1.201 (1.01–1.43)
0.039
192.5
0.71
TG COVID-19 severity 208 1.274 (1.08–1.50)
0.004
1.310 (1.03–1.67)
0.030
− 0.0013 (0.0040)
0.75
1.201 (0.92–1.57)
0.18
1.160 (0.91–1.47)
0.22
210.2
0.43
  1. Apo-B, apolipoprotein B; CI, confidence interval; COVID-19, coronavirus disease 2019; IVW, inverse variance weighted; LDL-C, low-density lipoprotein cholesterol; MR, Mendelian randomization; N, number; OR, odds ratio; SE, standard error; SNV, single nucleotide variant; TG, triglyceride