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Table 1 The results of logistic regression analysis for allelic association of SNP variants with T2DM, unadjusted and adjusted for covariates age, sex, migration, family history, physical activity, BMI, WHR

From: The genetic susceptibility profile of type 2 diabetes and reflection of its possible role related to reproductive dysfunctions in the southern Indian population of Hyderabad

Gene

SNP rs ID/nature of SNP

Major/minor allele

Minor allele frequency

χ2

Unadjusted

Adjusted for covariates

Cases

(N = 500)

Controls

(N = 500)

OR

(CI 0.95%)

P value

OR

(CI 0.95%)

P value

ADIPOQ

rs2241766

Non coding trancript variant

T/G

0.41

0.16

158

3.72 (3.01–4.60)

3.14 × 10–36

6.62 (4.82–9.08)

1.13 × 10–31

FEM1B

rs6494730

Utr variant

G/T

0.35

0.2

59.18

2.20 (1.80–2.70)

1.44 × 10–14

2.34 (1.78–3.08)

1.03 × 10–09

INSR

rs1799817

Exonic

G/A

0.15

0.24

29.05

0.54 (0.43–0.68)

7.07 × 10–08

0.53 (0.40–0.70)

1.35 × 10–05

rs2059806

Intronic

C/T

0.411

0.33

13.12

1.4 (1.17–1.68)

0.0002

1.36 (1.11–1.68)

0.003

rs7248104

Intronic

G/A

0.43

0.39

3.15

1.17 (0.98–1.40)

0.075#

1.29 (1.05–1.59)

0.017

FST

rs11745088

Exonic

G/C

0.01

0.04

15.25

0.28 (0.14–0.55)

9.41 × 10–05

0.27 (0.12–0.58)

0.001

FTO

rs9939609

Intronic

T/A

0.34

0.26

13.67

1.43 (1.18–1.73)

0.0002

1.38 (1.10–1.74)

0.004

rs9940128

Intronic

G/A

0.48

0.41

9.374

1.31 (1.10–1.57)

0.002

1.24 (1.00–1.53)

0.042

rs1421085

Intronic

T/C

0.38

0.33

5.92

1.26 (1.04–1.51)

0.010

1.21 (0.96–1.51)

0.103

rs17817449

Intronic

T/G

0.35

0.31

4.57

1.22 (1.02–1.48)

0.030

1.22 (0.97–1.53)

0.084

rs8050136

Intronic

C/A

0.36

0.31

4.55

1.22 (1.02–1.48)

0.030

1.24 (0.99–1.54)

0.065

IRS2

rs12584136

Intronic

C/A

0.03

0.05

5.76

0.55 (0.34–0.90)

0.016

0.63 (0.35–1.12)

0.117

rs1805097

Missense

C/T

0.03

0.01

5.11

2.03 (1.09–3.80)

0.023

1.54 (0.74–3.18)

0.239

LEPR

rs1805094

Exonic

G/C

0.09

0.12

4.25

0.74 (0.56–0.99)

0.039

0.83 (0.59–1.16)

0.265

c9orf3

rs3802457

Intronic

G/A

0.06

0.09

5.45

0.67 (0.48–0.94)

0.019

0.68 (0.46–1.00)

0.053

INSIG2

rs2161829

Intronic

G/A

0.487

0.45

2.9

1.16 (0.98–1.38)

0.088#

1.23 (1.00–1.51)

0.048

  1. SNPs in bold are significant after correction for multiple testing
  2. #P value turns out to be significant after adjusting for covariates