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Table 1 The results of logistic regression analysis for allelic association of SNP variants with T2DM, unadjusted and adjusted for covariates age, sex, migration, family history, physical activity, BMI, WHR

From: The genetic susceptibility profile of type 2 diabetes and reflection of its possible role related to reproductive dysfunctions in the southern Indian population of Hyderabad

Gene SNP rs ID/nature of SNP Major/minor allele Minor allele frequency χ2 Unadjusted Adjusted for covariates
Cases
(N = 500)
Controls
(N = 500)
OR
(CI 0.95%)
P value OR
(CI 0.95%)
P value
ADIPOQ rs2241766
Non coding trancript variant
T/G 0.41 0.16 158 3.72 (3.01–4.60) 3.14 × 10–36 6.62 (4.82–9.08) 1.13 × 10–31
FEM1B rs6494730
Utr variant
G/T 0.35 0.2 59.18 2.20 (1.80–2.70) 1.44 × 10–14 2.34 (1.78–3.08) 1.03 × 10–09
INSR rs1799817
Exonic
G/A 0.15 0.24 29.05 0.54 (0.43–0.68) 7.07 × 10–08 0.53 (0.40–0.70) 1.35 × 10–05
rs2059806
Intronic
C/T 0.411 0.33 13.12 1.4 (1.17–1.68) 0.0002 1.36 (1.11–1.68) 0.003
rs7248104
Intronic
G/A 0.43 0.39 3.15 1.17 (0.98–1.40) 0.075# 1.29 (1.05–1.59) 0.017
FST rs11745088
Exonic
G/C 0.01 0.04 15.25 0.28 (0.14–0.55) 9.41 × 10–05 0.27 (0.12–0.58) 0.001
FTO rs9939609
Intronic
T/A 0.34 0.26 13.67 1.43 (1.18–1.73) 0.0002 1.38 (1.10–1.74) 0.004
rs9940128
Intronic
G/A 0.48 0.41 9.374 1.31 (1.10–1.57) 0.002 1.24 (1.00–1.53) 0.042
rs1421085
Intronic
T/C 0.38 0.33 5.92 1.26 (1.04–1.51) 0.010 1.21 (0.96–1.51) 0.103
rs17817449
Intronic
T/G 0.35 0.31 4.57 1.22 (1.02–1.48) 0.030 1.22 (0.97–1.53) 0.084
rs8050136
Intronic
C/A 0.36 0.31 4.55 1.22 (1.02–1.48) 0.030 1.24 (0.99–1.54) 0.065
IRS2 rs12584136
Intronic
C/A 0.03 0.05 5.76 0.55 (0.34–0.90) 0.016 0.63 (0.35–1.12) 0.117
rs1805097
Missense
C/T 0.03 0.01 5.11 2.03 (1.09–3.80) 0.023 1.54 (0.74–3.18) 0.239
LEPR rs1805094
Exonic
G/C 0.09 0.12 4.25 0.74 (0.56–0.99) 0.039 0.83 (0.59–1.16) 0.265
c9orf3 rs3802457
Intronic
G/A 0.06 0.09 5.45 0.67 (0.48–0.94) 0.019 0.68 (0.46–1.00) 0.053
INSIG2 rs2161829
Intronic
G/A 0.487 0.45 2.9 1.16 (0.98–1.38) 0.088# 1.23 (1.00–1.51) 0.048
  1. SNPs in bold are significant after correction for multiple testing
  2. #P value turns out to be significant after adjusting for covariates