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Table 5 Haplotype association of variants with T2DM, unadjusted and adjusted for sex, age, migration, physical activity, BMI, WHR, family history

From: The genetic susceptibility profile of type 2 diabetes and reflection of its possible role related to reproductive dysfunctions in the southern Indian population of Hyderabad

Haplotype block number/ gene SNPs in the haplotype block Associated haplotype Frequency χ2 Unadjusted Adjusted
Cases
(N = 500)
Controls
(N = 500)
OR P value OR P value
1/PRKAA2 rs11206887
rs2143749
AC 0.19 0.21 0.285 0.941 0.581 0.960 0.783
2/ LEPR rs1137101
rs1805094
AC 0.09 0.12 3.769 0.755 0.054 0.850 0.345
3/POMC rs1042571
rs12473543
AT 0.07 0.06 2.187 1.320 0.126 1.320 0.206
3/ IRS2 rs754204
rs7987237
TC 0.45 0.47 0.973 1.070 0.476 0.920 0.444
4/ FTO rs17817449
rs8050136
rs9939609
GAT 0.02 0.05 14.97 0.376 0.001* 0.410 0.004*
5/INSR rs2115386
rs1035942
CA 0.31 0.28 0.999 1.100 0.316 1.120 0.302
6/INSR rs4804416
rs7248104
TA 0.43 0.38 3.167 1.170 0.079 1.300 0.015*
7/FBN3 rs17202517
rs73503752
AT 0.13 0.15 0.424 0.916 0.500 0.910 0.547
  1. *Significant P value