The genetic susceptibility profile of type 2 diabetes and reflection of its possible role related to reproductive dysfunctions in the southern Indian population of Hyderabad

Table 5 Haplotype association of variants with T2DM, unadjusted and adjusted for sex, age, migration, physical activity, BMI, WHR, family history

Haplotype block number/ gene	SNPs in the haplotype block	Associated haplotype	Frequency		χ²	Unadjusted		Adjusted
Haplotype block number/ gene	SNPs in the haplotype block	Associated haplotype	Cases (N = 500)	Controls (N = 500)	χ²	OR	P value	OR	P value
1/PRKAA2	rs11206887 rs2143749	AC	0.19	0.21	0.285	0.941	0.581	0.960	0.783
2/ LEPR	rs1137101 rs1805094	AC	0.09	0.12	3.769	0.755	0.054	0.850	0.345
3/POMC	rs1042571 rs12473543	AT	0.07	0.06	2.187	1.320	0.126	1.320	0.206
3/ IRS2	rs754204 rs7987237	TC	0.45	0.47	0.973	1.070	0.476	0.920	0.444
4/ FTO	rs17817449 rs8050136 rs9939609	GAT	0.02	0.05	14.97	0.376	0.001*	0.410	0.004*
5/INSR	rs2115386 rs1035942	CA	0.31	0.28	0.999	1.100	0.316	1.120	0.302
6/INSR	rs4804416 rs7248104	TA	0.43	0.38	3.167	1.170	0.079	1.300	0.015*
7/FBN3	rs17202517 rs73503752	AT	0.13	0.15	0.424	0.916	0.500	0.910	0.547

ISSN: 1755-8794