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Table 7 Summary of allelic association results in the male and female subsets of T2DM

From: The genetic susceptibility profile of type 2 diabetes and reflection of its possible role related to reproductive dysfunctions in the southern Indian population of Hyderabad

S. No Gene SNP T2DM males* T2DM females*
Odds ratio P value Odds ratio P value
Diabetic genes       
1 INSR rs1799817 0.49(0.37–0.66) 1.85 × 10–06 0.61(0.42–0.89) 0.010
rs2059806 1.38(1.10–1.74) 0.004 1.45(1.06–1.98) 0.018
rs2115386ǂ 1.50(1.11–2.02) 0.007
rs1035942ǂ 1.48(1.07–2.06) 0.017
2 IRS2 rs12584136 0.38(0.16–0.89) 0.021
rs1805097 2.04(0.99–4.22) 0.047
3 INSIG2 rs2161829ǂ 1.41(1.05–1.90) 0.021
Obesity genes       
4 ADIPOQ rs2241766 4.00(3.06–5.22) 5.42 × 10–26 3.14(2.21–4.45) 4.77 × 10–11
5 FTO rs9939609 1.51(1.19–1.91) 0.001
rs9940128 1.29(1.04–1.61) 0.021 1.46(1.08–1.99) 0.013
rs1421085 1.31(1.05–1.65) 0.017
rs17817449#
rs8050136#
6 LEPR rs1805094 0.68(0.47–0.98) 0.041
Reproductive genes       
7 FEM1 rs6494730 2.40(1.85–3.12) 2.34 × 10–11 1.76(1.27–2.45) 0.001
8 FST rs11745088 0.14(0.05–0.42) 4.44 × 10–05
9 FBN3 rs17202517ǂ 0.67(0.49–0.91) 0.010 1.73(1.13–2.67) 0.011
rs73503752ǂ 0.72(0.53–0.99) 0.048 1.59(1.02–2.46) 0.036
10 ESR2 rs1256049ǂ 0.58(0.41–0.82) 0.002 0.51(0.32–0.80) 0.003
Other genes       
11 PRKAG3 rs6436094ǂ 0.68(0.50–0.94) 0.021
12 c9orf3 rs3802457 0.55(0.36–0.83) 0.004
  1. P values in bold indicate significant after correction for multiple testing
  2. ǂFound only in subsets
  3. #Associated only in pooled set
  4. *Sample size: Male cohort—290 cases and 350 controls; female cohort—210 cases and 150 controls