Table 7 Summary of allelic association results in the male and female subsets of T2DM

Diabetic genes

1

INSR

rs1799817

0.49(0.37–0.66)

1.85 × 10^–06

0.61(0.42–0.89)

rs2059806

1.38(1.10–1.74)

0.004

1.45(1.06–1.98)

rs2115386^ǂ

–

–

1.50(1.11–2.02)

rs1035942^ǂ

–

–

1.48(1.07–2.06)

2

IRS2

rs12584136

–

–

0.38(0.16–0.89)

rs1805097

2.04(0.99–4.22)

0.047

–

3

INSIG2

rs2161829^ǂ

–

–

1.41(1.05–1.90)

Obesity genes

4

ADIPOQ

rs2241766

4.00(3.06–5.22)

5.42 × 10^–26

3.14(2.21–4.45)

5

FTO

rs9939609

1.51(1.19–1.91)

0.001

–

rs9940128

1.29(1.04–1.61)

0.021

1.46(1.08–1.99)

rs1421085

1.31(1.05–1.65)

0.017

–

rs17817449^#

–

–

–

rs8050136^#

–

–

–

6

LEPR

rs1805094

0.68(0.47–0.98)

0.041

–

Reproductive genes

7

FEM1

rs6494730

2.40(1.85–3.12)

2.34 × 10^–11

1.76(1.27–2.45)

8

FST

rs11745088

0.14(0.05–0.42)

4.44 × 10^–05

–

9

FBN3

rs17202517^ǂ

0.67(0.49–0.91)

0.010

1.73(1.13–2.67)

rs73503752^ǂ

0.72(0.53–0.99)

0.048

1.59(1.02–2.46)

10

ESR2

rs1256049^ǂ

0.58(0.41–0.82)

0.002

0.51(0.32–0.80)

Other genes

11

PRKAG3

rs6436094^ǂ

–

–

0.68(0.50–0.94)

12

c9orf3

rs3802457

0.55(0.36–0.83)

0.004

–