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Fig. 1 | BMC Medical Genomics

Fig. 1

From: Integrative multi-omics identifies high risk multiple myeloma subgroup associated with significant DNA loss and dysregulated DNA repair and cell cycle pathways

Fig. 1

Twelve multiple myeloma subgroups identified by integrative clustering. A Figure representing a visual summary of the work presented in the paper. From NDMM molecular profiles to identification of HR patient segment by multi-omics unsupervised clustering and its main characteristics including genomic loss, master regulators and DNA repair and cell cycle dysregulation. B Heatmap showing molecular characteristics of the molecularly defined myeloma subgroups (MDMS 1-12): Left panel shows copy number variants with structural variants added as tracks above; middle panel shows gene expression (top 30 over-expressed genes per MDMS without replication); and right panel shows single nucleotide variants (black band denotes mutation, white band denotes wild-type sequence)

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BMC Medical Genomics

ISSN: 1755-8794

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