An intron SNP rs2069837 in IL-6 is associated with osteonecrosis of the femoral head development

Wang, Ruisong; Li, Rui; Liu, Ruiyu

doi:10.1186/s12920-021-01142-3

BMC Medical Genomics

Table 5 False positive report probability of the association rs2069837 and ONFH susceptibility in subgroups

From: An intron SNP rs2069837 in IL-6 is associated with osteonecrosis of the femoral head development

Model and variables	Genotype	OR (95% CI)	p^a	Statistical power	Prior probability
Model and variables	Genotype	OR (95% CI)	p^a	Statistical power	0.25	0.1	0.01	0.001	0.0001
Overall analysis
Allele	G versus A	0.76 (0.62–0.93)	0.009	0.898	0.025^b	0.072^b	0.459	0.896	0.988
Heterozygote	AG versus AA	0.75 (0.58–0.96)	0.023	0.825	0.075^b	0.196^b	0.729	0.964	0.996
Dominant	GG + AG versus AA	0.73 (0.57–0.93)	0.011	0.769	0.041^b	0.113^b	0.583	0.934	0.993
Additive	/	0.76 (0.62–0.93)	0.009	0.898	0.025^b	0.072^b	0.459	0.896	0.988
Stratification analysis
Male
Allele	G versus A	0.73 (0.55–0.96)	0.023	0.997	0.068^b	0.180^b	0.707	0.961	0.996
Heterozygote	AG versus AA	0.70 (0.50–0.98)	0.037	0.975	0.104^b	0.258	0.793	0.975	0.997
Dominant	GG + AG versus AA	0.68 (0.49–0.95)	0.022	0.964	0.069^b	0.182^b	0.709	0.961	0.996
Additive	/	0.72 (0.54–0.95)	0.022	0.995	0.057^b	0.154^b	0.668	0.953	0.995
> 51 years
Allele	G versus A	0.69 (0.52–0.91)	0.009	0.989	0.025^b	0.073^b	0.462	0.897	0.989
Heterozygote	AG versus AA	0.69 (0.49–0.98)	0.036	0.964	0.106^b	0.263	0.797	0.975	0.997
Dominant	GG + AG versus AA	0.66 (0.48–0.92)	0.015	0.949	0.043^b	0.119^b	0.597	0.937	0.993
Additive	/	0.68 (0.51–0.90)	0.008	0.984	0.021^b	0.060^b	0.413	0.877	0.986
Non-smoking
Allele	G versus A	0.72 (0.53–0.97)	0.029	0.992	0.085^b	0.218	0.754	0.969	0.997
Heterozygote	AG versus AA	0.69 (0.48–0.99)	0.046	0.960	0.121^b	0.292	0.819	0.979	0.998
Dominant	GG + AG versus AA	0.68 (0.48–0.96)	0.029	0.960	0.081^b	0.210	0.745	0.967	0.997
Additive	/	0.71 (0.52–0.96)	0.026	0.989	0.073^b	0.192^b	0.723	0.963	0.996
Non-drinking
Heterozygote	AG versus AA	0.69 (0.48–1.00)	0.048	0.956	0.136^b	0.320	0.838	0.981	0.998
Dominant	GG + AG versus AA	0.69 (0.49–0.98)	0.040	0.964	0.106^b	0.263	0.797	0.975	0.997

OR odds ratio, CI confidence interval
^ap < 0.05 indicates statistical significance
^bThe level of false positive report probability threshold was set at 0.2 and noteworthy findings are presented

Back to article page

ISSN: 1755-8794

Contact us

Submission enquiries: bmcmedicalgenomics@biomedcentral.com
General enquiries: ORSupport@springernature.com