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Table 5 False positive report probability of the association rs2069837 and ONFH susceptibility in subgroups

From: An intron SNP rs2069837 in IL-6 is associated with osteonecrosis of the femoral head development

Model and variables Genotype OR (95% CI) pa Statistical power Prior probability
0.25 0.1 0.01 0.001 0.0001
Overall analysis
 Allele G versus A 0.76 (0.62–0.93) 0.009 0.898 0.025b 0.072b 0.459 0.896 0.988
 Heterozygote AG versus AA 0.75 (0.58–0.96) 0.023 0.825 0.075b 0.196b 0.729 0.964 0.996
 Dominant GG + AG versus AA 0.73 (0.57–0.93) 0.011 0.769 0.041b 0.113b 0.583 0.934 0.993
 Additive / 0.76 (0.62–0.93) 0.009 0.898 0.025b 0.072b 0.459 0.896 0.988
Stratification analysis
 Male
  Allele G versus A 0.73 (0.55–0.96) 0.023 0.997 0.068b 0.180b 0.707 0.961 0.996
  Heterozygote AG versus AA 0.70 (0.50–0.98) 0.037 0.975 0.104b 0.258 0.793 0.975 0.997
  Dominant GG + AG versus AA 0.68 (0.49–0.95) 0.022 0.964 0.069b 0.182b 0.709 0.961 0.996
  Additive / 0.72 (0.54–0.95) 0.022 0.995 0.057b 0.154b 0.668 0.953 0.995
 > 51 years
  Allele G versus A 0.69 (0.52–0.91) 0.009 0.989 0.025b 0.073b 0.462 0.897 0.989
  Heterozygote AG versus AA 0.69 (0.49–0.98) 0.036 0.964 0.106b 0.263 0.797 0.975 0.997
  Dominant GG + AG versus AA 0.66 (0.48–0.92) 0.015 0.949 0.043b 0.119b 0.597 0.937 0.993
  Additive / 0.68 (0.51–0.90) 0.008 0.984 0.021b 0.060b 0.413 0.877 0.986
 Non-smoking
  Allele G versus A 0.72 (0.53–0.97) 0.029 0.992 0.085b 0.218 0.754 0.969 0.997
  Heterozygote AG versus AA 0.69 (0.48–0.99) 0.046 0.960 0.121b 0.292 0.819 0.979 0.998
  Dominant GG + AG versus AA 0.68 (0.48–0.96) 0.029 0.960 0.081b 0.210 0.745 0.967 0.997
  Additive / 0.71 (0.52–0.96) 0.026 0.989 0.073b 0.192b 0.723 0.963 0.996
 Non-drinking
  Heterozygote AG versus AA 0.69 (0.48–1.00) 0.048 0.956 0.136b 0.320 0.838 0.981 0.998
  Dominant GG + AG versus AA 0.69 (0.49–0.98) 0.040 0.964 0.106b 0.263 0.797 0.975 0.997
  1. OR odds ratio, CI confidence interval
  2. ap < 0.05 indicates statistical significance
  3. bThe level of false positive report probability threshold was set at 0.2 and noteworthy findings are presented