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Table 3 Distribution of SMAD7 genotypes and allele frequency among colorectal cancer patients and controls

From: Association of SMAD7 genetic markers and haplotypes with colorectal cancer risk

Genetic model (HWE) Genotype Cases (n = 209) Controls (n = 200) p-value OR (95%CI) p-valueadj.* OR (95%CI) adj.*
rs4939827 (0.1) CC 89(42.6%) 78(40.0%)    Ref  
CT 83(39.7%) 101(51.8%) 0.12 0.72(0.47–1.09) 0.294 0.75(0.43–1.29)
TT 37(17.7%) 16(8.2%) 0.036 2.02(1.04–3.92) 0.024 2.49(1.13–4.49)
Dominant model TT + CT 120 (57.4%) 117 (60.0%)    Ref  
CC 89(42.6%) 78(40.0%) 0.598 1.11(0.75–1.65) 0.920 1.03(0.62–1.70)
Recessive model CC + CT 172 (82.3%) 179 (91.8%)    Ref  
TT 37(17.7%) 16(8.2%) 0.006 2.40(1.29–4.48) 0.005 2.90(1.38–6.09)
Multiplicative model C 157(37.6%) 133(34.1%)    Ref  
T 261(62.4%) 257(65.9%) 0.350 0.87 (0.65–1.16) 0.189 0.78 (0.54–1.13)
Co-dominant model CT 83(39.7%) 101(51.8%)    Ref  
CC + TT 126 (60.3%) 94 (48.2%) 0.015 1.63 (1.10–2.42) 0.049 1.66 (1.00–2.75)
rs34007497 (0.98) CC 135 (64.6%) 126 (63.0%)    Ref  
CG 52 (24.9%) 66 (33.0%) 0.168 0.73(0.47–1.14) 0.183 0.68 (0.39–1.20)
GG 22 (10.5%) 8 (4.0%) 0.029 2.56 (1.10–5.97) 0.327 1.71 (0.558–5.04)
Recessive model CC + CG 187 (89.5%) 192 (96.0%)    Ref  
GG 22 (10.5%) 8 (4.0%) 0.015 2.82(1.22–4.50) 0.227 1.93 (0.66–5.59)
Dominant model GG + CG 74 (35.4%) 74 (37.0%)    Ref  
CC 135 (64.6%) 126 (63.0%) 0.737 1.07(0.71–1.60) 0.379 0.79 (0.47–1.33)
Multiplicative model C 96 (22.9%) 82 (20.5%)    Ref  
G 322 (77.1%) 318 (79.5%) 0.393 1.16(0.83–1.63) 0.788 0.94 (0.61–1.46)
Co-dominant model CC + GG 157 (75.1%) 134 (67.0%)    Ref  
CG 52 (24.9%) 66 (33.0%) 0.071 0.67 (0.44–1.03) 0.135 0.65 (0.37–1.14)
rs8085824 (0.53) TT 58 (28.9%) 77 (38.5%)    Ref  
CT 97 (48.3%) 100 (50.0%) 0.013 0.48 (0.27–0.86) 0.092 0.53 (0.26–1.11)
CC 46 (22.8%) 23 (11.5%) 0.002 2.06 (1.45–4.86) 0.086 1.95 (0.91–4.20)
Recessive model CT + TT 155 (77.1%) 177 (88.5%)    Ref  
CC 46 (22.9%) 23 (11.5%) 0.042 1.54 (1.02–2.34) 0.477 1.21 (0.71–2.07)
Dominant model CC + CT 143 (71.1%) 123 (61.5%)    Ref  
TT 58 (28.9%) 77 (38.5%) 0.003 0.44 (0.25–0.75) 0.067 0.52 (0.26–1.05)
Multiplicative model T 189 (56.4%) 213 (45.6%)    Ref  
C 146 (43.6%) 254 (54.4%) 0.003 0.65 (0.49–0.86) 0.150 0.76 (0.53–1.10)
Co-dominant model CC + TT 104 (51.7%) 100 (50.0%)    Ref  
CT 97 (48.3%) 100 (50.0%) 0.727 0.93 (0.63–1.38) 0.537 0.85 (0.51–1.42)
rs8088297 (0.67) CC 3 (1.4%) 3 (1.5%)    Ref  
AC 15 (7.2%) 33 (16.5%) 0.367 0.35 (0.08–2.52) 0.306 0.35 (0.05–2.62)
AA 191 (91.4%) 164 (82.0%) 0.853 1.16 (0.23–5.85) 0.645 1.55 (0.23–10.33)
Recessive model CC + AC 18 (8.6%) 36 (18.0%)    Ref  
AA 191 (91.4%) 164 (82.0%) 0.006 2.33 (1.27–4.26) 0.203 1.62 (0.77–3.40)
Dominant model AA + AC 206 (98.6%) 197 (98.5%)    Ref  
CC 3 (1.4%) 3 (1.5%) 0.957 0.96 (0.19–4.79) 0.587 0.59 (0.09–3.92)
Multiplicative model C 21 (5.02%) 39 (9.7%)    Ref  
A 397 (94.98%) 361 (90.3%) 0.011 2.04 (1.18–3.54) 0.319 1.41 (0.72–2.75)
Co-dominant model CC + AA 194 (92.8%) 167 (83.5%)    Ref  
AC 15 (7.2%) 33 (16.5%) 0.004 0.39 (0.20–0.74) 0.129 0.54 (0.24–1.20)
  1. All statistically significant P-values are shown in bold
  2. *Adjusted for age, sex and BMI