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Fig. 4 | BMC Medical Genomics

Fig. 4

From: Clinicopathological investigation of secretory carcinoma cases including a successful treatment outcome using entrectinib for high-grade transformation: a case report

Fig. 4

Representative immunohistochemical findings of S-100 protein (AC) and mammaglobin (D and E) in SC cases. The tumor cells show strong and diffuse staining for S-100 protein in Case 1 (A) and the initial tumor of Case 3 (B), whereas the neoplastic cells in the specimen from the 6th recurrence of Case 3 were negative for S-100 protein (C). D The tumor cells also show strong and diffuse staining for mammaglobin (Case 1). E The HG component displays a low level of mammaglobin expression (right portion), in contrast to a high level of mammaglobin expression in the LG component (left portion, Case 2). Scale bars, 100 µm (AD); 500 µm (E)

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