Fig. 5

Immunohistochemical findings of Ki-67 in Case 2 (A) and Case 3 (B and C), and p53 (D and E) in Case 3. A The HG component displays a high Ki-67 LI (right portion), in contrast to a low Ki-67 LI in the LG component (left portion, Case 2). B and D, the initial tumor; C and E, the specimen from the 6th recurrence. Ki-67 LI (C) and the p53-positive cell population (E) were markedly higher in the recurrent tumor compared with the initial tumor (B and D, respectively). Scale bars, 500 µm (A); 50 µm (B–E)