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Table 2 Details of NGS analysis in 6 samples from 3 cases of SC

From: Clinicopathological investigation of secretory carcinoma cases including a successful treatment outcome using entrectinib for high-grade transformation: a case report

Case# Specimen site Sample collection date RNA input (ng) Gene fusion No. valid fusion reads % of reads supporting fusion No. unique start sites Breakpoints
1 Parotid 2015 100 ETV6-NTRK3 6 10.17 3 chr12:12022903 chr15:88483984
     NTRK3-ETV6† 8 13.56 3 chr15:88576088 chr12:12037379
2 Lymph node 2016 100 ETV6-NTRK3 232 60.42 104 chr12:12022903 chr15:88483984
     NTRK3-ETV6† 100 49.75 53 chr15:88576088 chr12:12037379
3–1* Parotid 1994 100 ETV6-NTRK3 29 24.17 14 chr12:12022903 chr15:88483984
3–2* Parotid 2008 100 ETV6-NTRK3 14 17.72 9 chr12:12022903 chr15:88483984
3–3* Parotid 2012 100 ETV6-NTRK3 873 57.62 167 chr12:12022903 chr15:88483984
3–4* Lymph node 2012 100 ETV6-NTRK3 288 56.58 104 chr12:12022903 chr15:88483984
  1. *3–1, the initial tumor; 3–2, 3rd recurrence; 3–3, 5th recurrence; 3–4, and 6th recurrence of case 3, respectively
  2. †Reciprocal fusion which is secondary and non –driver mutation
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BMC Medical Genomics

ISSN: 1755-8794

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