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Fig. 2 | BMC Medical Genomics

Fig. 2

From: Evaluating the association of TRPA1 gene polymorphisms with pain sensitivity: a protocol for an adaptive recall by genotype study

Fig. 2

Schematic of study design showing the 4 potential outcomes of the adaptive design. The trial progresses from left to right until the full sample of 100 is recruited. Each allele cohort is noted with uniquely coloured human icon with the numbers recruited in that phase noted underneath. Interim assesments are marked with a magnifying glass with the effect size ‘d’ criteria to continue the trial noted and alpha thresholds for subsequent t-test. Note that the trial will adapt due to small effect sizes and also if the hypothesis test passess due efficacy. The final “?” represents that this final cohort could be from any of the final cohorts based on assesment of other outcomes. For further details on the outcome criteria see Table 2

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