Fig. 2

Hsa_circ_0086354 is a potential biomarker for early diagnosis of CP. Five circRNAs screened out by microarray was further validated by quantitative real-time PCR. A All expression levels in Control group were normalized to “1”. Fold changes of CP versus Control obtained from microarray and real-time PCR were shown. B Relative expression of hsa_circ_0086354 in 30 pairs of CP and Control samples detected by quantitative real-time PCR was shown. C ROC curve analysis was carried out to assess the value of hsa_circ_0086354 in discriminating children with CP and healthy controls. The AUC was 0.967, the sensitivity was 0.833 and the specificity was 0.966. “ns”: not significant; ***p < 0.001. CP cerebral palsy, ROC receiver operating characteristic, AUC area under the curve