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Fig. 2 | BMC Medical Genomics

Fig. 2

From: A novel missense variant in ESRRB gene causing autosomal recessive non-syndromic hearing loss: in silico analysis of a case

Fig. 2

(A) Visualization of multiple sequence alignment of the ESRRB protein in mammals including the missense mutation site. The location of the altered amino acid has been indicated in the black box. (B) Molecular modelling of the ESRRB protein. The wild-type residue (Gly167) of the ESRRB protein has been depicted with violet. (a) Molecular modeling predicted hydrogen interaction between Gly167 and Ala163 residues. Hydrogen bonds have been shown with the yellow dotted line. (b) the large side chain of Arg in the 167th position possibly increases inappropriate interaction between residues

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