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Table 2 VIP Interpretation of all variants from DECIPHER

From: GeneTerpret: a customizable multilayer approach to genomic variant prioritization and interpretation

Clinical significance VIP (Automated Pathogenicity Identifier module) DECIPHER (Manual Pathogenicity Identifier) Concordant
Benign 14 (0.1%) 23 (0.3%) 0 (0%)
Likely Benign 81 (0.9%) 211 (2.4%) 9 (0.2%)
Uncertain significance 3633 (42.2%) 3329 (38.6%) 2202 (48.9%)
Likely pathogenic 2692 (31.3%) 2508 (29.1%) 1055 (23.4%)
Pathogenic 2190 (25.4%) 2539 (29.5%) 1240 (27.5%)
Sum of five tiers 8610 8610 4506
Benign or likely benign 95 (1.1%) 234 (2.7%) 9 (0.2%)
Pathogenic or likely pathogenic 4882 (56.7%) 5047 (58.6%) 3764 (83.5%)