Alterations in chromatin accessibility during osteoblast and adipocyte differentiation in human mesenchymal stem cells

Table 2 The 10 top-ranking motifs that changed with differentiation in each group

Rank	AD3 versus MSC		AD5 versus MSC		AD7 versus MSC		OB3 versus MSC		OB5 versus MSC		OB7 versus MSC
Rank	Up	Down	Up	Down	Up	Down	Up	Down	Up	Down	Up	Down
1	CEBP	Atf3	CEBP	Fra1	TEAD3	Fra1	TEAD3	Fra1	RUNX1	Atf3	CEBP	Fra1
2	NFIL3	Fra1	CEBP:AP1	Atf3	TEAD1	Atf3	TEAD1	Atf3	TEAD1	Fra1	EBF2	Atf3
3	HLF	BATF	HLF	BATF	TEAD4	BATF	TEAD4	AP-1	TEAD3	AP-1	NFIL3	BATF
4	EBF2	AP-1	NFIL3	Fra2	TEAD	AP-1	RUNX	BATF	TEAD4	BATF	HLF	Fra2
5	CEBP:AP1	JunB	RUNX1	AP-1	CEBP	Fra2	RUNX1	JunB	RUNX2	JunB	CEBP:AP1	JunB
6	NF1	Fra2	EBF2	JunB	RUNX2	JunB	RUNX2	Fra2	RUNX-AML	Fra2	NF1	AP-1
7	Atf4	Fosl2	RUNX2	Fosl2	RUNX1	Fosl2	CEBP	Fosl2	TEAD2	Fosl2	EBF1	Fosl2
8	EBF1	Jun-AP1	RUNX-AML	Jun-AP1	NF1	Jun-AP1	TEAD2	Jun-AP1	CEBP	Jun-AP1	Atf4	Jun-AP1
9	GRE	Bach2	Atf4	Bach2	RUNX-AML	Bach2	RUNX-AML	Bach2	NF1	Bach2	GRE	Bach2
10	EBF	MafK	NF1	MafK	TEAD2	MafK	CEBP:AP1	Bach1	CEBP:AP1	Bach1	ARE	Bach1

ISSN: 1755-8794