Genetic polymorphism of ADAM17 and decreased bilirubin levels are associated with allergic march in the Korean population

Table 3 RegulomeDB results of SNPs in the ADAM17

Gene	SNP	BP	A1	A2	RegulomeDB
Gene	SNP	BP	A1	A2	Score	eQTL	TFBS	DNase	Proteins bound	Motifs
ADAM17	rs17524376	9,542,245	A	T	2b	–	+	+	BCL3, POLR2A, RAD21,	NFYB, NFYA, NFYC
	rs6432011	9,542,900	C	T	1f	ADAM17	+	+	–	OSR1
	rs4319913	9,543,433	T	C	1f	ADAM17	+	+	–	–
	rs17524425	9,543,455	C	T	1f	ADAM17, ITGB1BP1	+	+	–	–
	rs4622692	9,550,588	C	A	1f	ADAM17	+	+	–	–
	rs7580419	9,563,839	A	G	1f	ADAM17	+	+	–	–
	rs11684747	9,614,622	C	T	1f	ADAM17, ITGB1BP1	+	+	HDAC1, SMARCA4, KDM5A, RFX3, MBD4, ATF3, ZNF318	–

BP, base pair; A1, minor allele; A2, major allele; eQTL, expression quantitative trait loci; TFBS, transcription factor binding site

ISSN: 1755-8794