Table 3 Frequencies of CYP 2C8, 3A5 and 3A4 polymorphisms
Oligonucleotide primer | Allele frequency | Genotype | n (%) | HWE P-value | |
|---|---|---|---|---|---|
CYP2C8 (rs1058932) | r 5′-CTAGCCCATCTGGCTGC-3′ | A = 35.3% | A/A | 23 (15.8) | 0.79740 |
G = 64.7% | A/G | 57 (39.0) | |||
G/G | 66 (45.2) | ||||
CYP2C8 (rs10882526) | f 5′-TCAACTCACTCCGCT-3′ | A = 87.0% | G/G | 3 (2.1) | 0.69981 |
G = 13.0% | A/A | 111 (76) | |||
A/G | 32 (21.9) | ||||
CYP3A5 (rs776746) | f 5′-TCCAAACAGGGAAGAGATA-3′ | C = 79.1% | C/T | 55 (37.7) | 0.77629 |
T = 20.9% | T/T | 8 (5.5) | |||
C/C | 83 (56.8) | ||||
CYP3A4 (rs3735451) | f5′-AACAGAGTGATATTCTGATCTC-3′ | C = 26.7% | C/C | 10 (6.9) | 0.85980 |
T = 73.3% | C/T | 58 (39.7) | |||
T/T | 78 (53.4) |