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Table 3 Frequencies of CYP 2C8, 3A5 and 3A4 polymorphisms

From: Relationship of cytochrome P450 gene polymorphisms with blood concentrations of hydroxychloroquine and its metabolites and adverse drug reactions

  Oligonucleotide primer Allele frequency Genotype n (%) HWE P-value
CYP2C8 (rs1058932) r 5′-CTAGCCCATCTGGCTGC-3′ A = 35.3% A/A 23 (15.8) 0.79740
G = 64.7% A/G 57 (39.0)
G/G 66 (45.2)
CYP2C8 (rs10882526) f 5′-TCAACTCACTCCGCT-3′ A = 87.0% G/G 3 (2.1) 0.69981
G = 13.0% A/A 111 (76)
A/G 32 (21.9)
CYP3A5 (rs776746) f 5′-TCCAAACAGGGAAGAGATA-3′ C = 79.1% C/T 55 (37.7) 0.77629
T = 20.9% T/T 8 (5.5)
C/C 83 (56.8)
CYP3A4 (rs3735451) f5′-AACAGAGTGATATTCTGATCTC-3′ C = 26.7% C/C 10 (6.9) 0.85980
T = 73.3% C/T 58 (39.7)
T/T 78 (53.4)
  1. Values are the number (%)