Relationship of cytochrome P450 gene polymorphisms with blood concentrations of hydroxychloroquine and its metabolites and adverse drug reactions

Table 3 Frequencies of CYP 2C8, 3A5 and 3A4 polymorphisms

	Oligonucleotide primer	Allele frequency	Genotype	n (%)	HWE P-value
CYP2C8 (rs1058932)	r 5′-CTAGCCCATCTGGCTGC-3′	A = 35.3%	A/A	23 (15.8)	0.79740
		G = 64.7%	A/G	57 (39.0)
		G = 64.7%	G/G	66 (45.2)
CYP2C8 (rs10882526)	f 5′-TCAACTCACTCCGCT-3′	A = 87.0%	G/G	3 (2.1)	0.69981
		G = 13.0%	A/A	111 (76)
		G = 13.0%	A/G	32 (21.9)
CYP3A5 (rs776746)	f 5′-TCCAAACAGGGAAGAGATA-3′	C = 79.1%	C/T	55 (37.7)	0.77629
		T = 20.9%	T/T	8 (5.5)
		T = 20.9%	C/C	83 (56.8)
CYP3A4 (rs3735451)	f5′-AACAGAGTGATATTCTGATCTC-3′	C = 26.7%	C/C	10 (6.9)	0.85980
		T = 73.3%	C/T	58 (39.7)
		T = 73.3%	T/T	78 (53.4)

ISSN: 1755-8794