Table 5 Results of average blood concentrations of HCQ and its metabolites in SLE and RA patients with different CYP3A4 genotypes
SNP | Group | Genotype | n | Blood concentration (ng/ml) | P | |
|---|---|---|---|---|---|---|
Unadjusted model | rs3735451 | HCQ | CC | 8 | 742.4 ± 542.6* | 0.033 |
CT | 53 | 723.8 ± 532.9 | ||||
TT | 69 | 742.1 ± 543.9 | ||||
DHCQ | CC | 8 | 512.3 ± 365.4 | |||
CT | 53 | 500.1 ± 358.1 | ||||
TT | 69 | 512.1 ± 367.4 | ||||
DCQ | CC | 8 | 298.0 ± 200.3* | 0.039 | ||
CT | 53 | 293.3 ± 198.8 | ||||
TT | 69 | 299.5 ± 202.9 | ||||
BDCQ | CC | 8 | 48.9 ± 39.2* | 0.033 | ||
CT | 53 | 48.0 ± 38.5 | ||||
TT | 69 | 48.8 ± 39.0 | ||||
Adjusted Model# | rs3735451 | HCQ | CC | 10 | 759.9 ± 569.6* | 0.017 |
CT | 58 | 795.9 ± 651.9 | ||||
TT | 78 | 797.0 ± 651.9 | ||||
DHCQ | CC | 10 | 519.8 ± 381.6 | |||
CT | 58 | 553.5 ± 452.8 | ||||
TT | 78 | 554.1 ± 454.0 | ||||
DCQ | CC | 10 | 305.6 ± 271.3* | 0.047 | ||
CT | 58 | 322.3 ± 239.3 | ||||
TT | 78 | 322.7 ± 241.0 | ||||
BDCQ | CC | 10 | 49.7 ± 40.4* | 0.005 | ||
CT | 58 | 53.5 ± 52.5 | ||||
TT | 78 | 53.3 ± 52.4 |