| |
SNP
|
Group
|
Genotype
|
n
|
Blood concentration (ng/ml)
|
P
|
|---|
|
Unadjusted model
|
rs3735451
|
HCQ
|
CC
|
8
|
742.4 ± 542.6*
|
0.033
|
| | | |
CT
|
53
|
723.8 ± 532.9
| |
| | | |
TT
|
69
|
742.1 ± 543.9
| |
| | |
DHCQ
|
CC
|
8
|
512.3 ± 365.4
| |
| | | |
CT
|
53
|
500.1 ± 358.1
| |
| | | |
TT
|
69
|
512.1 ± 367.4
| |
| | |
DCQ
|
CC
|
8
|
298.0 ± 200.3*
|
0.039
|
| | | |
CT
|
53
|
293.3 ± 198.8
| |
| | | |
TT
|
69
|
299.5 ± 202.9
| |
| | |
BDCQ
|
CC
|
8
|
48.9 ± 39.2*
|
0.033
|
| | | |
CT
|
53
|
48.0 ± 38.5
| |
| | | |
TT
|
69
|
48.8 ± 39.0
| |
|
Adjusted Model#
|
rs3735451
|
HCQ
|
CC
|
10
|
759.9 ± 569.6*
|
0.017
|
| | | |
CT
|
58
|
795.9 ± 651.9
| |
| | | |
TT
|
78
|
797.0 ± 651.9
| |
| | |
DHCQ
|
CC
|
10
|
519.8 ± 381.6
| |
| | | |
CT
|
58
|
553.5 ± 452.8
| |
| | | |
TT
|
78
|
554.1 ± 454.0
| |
| | |
DCQ
|
CC
|
10
|
305.6 ± 271.3*
|
0.047
|
| | | |
CT
|
58
|
322.3 ± 239.3
| |
| | | |
TT
|
78
|
322.7 ± 241.0
| |
| | |
BDCQ
|
CC
|
10
|
49.7 ± 40.4*
|
0.005
|
| | | |
CT
|
58
|
53.5 ± 52.5
| |
| | | |
TT
|
78
|
53.3 ± 52.4
| |
- Note: vs. CT genotype, *P < 0.05 #: Adjusted for duration of use
