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Table 5 Results of average blood concentrations of HCQ and its metabolites in SLE and RA patients with different CYP3A4 genotypes

From: Relationship of cytochrome P450 gene polymorphisms with blood concentrations of hydroxychloroquine and its metabolites and adverse drug reactions

  SNP Group Genotype n Blood concentration (ng/ml) P
Unadjusted model rs3735451 HCQ CC 8 742.4 ± 542.6* 0.033
    CT 53 723.8 ± 532.9  
    TT 69 742.1 ± 543.9  
   DHCQ CC 8 512.3 ± 365.4  
    CT 53 500.1 ± 358.1  
    TT 69 512.1 ± 367.4  
   DCQ CC 8 298.0 ± 200.3* 0.039
    CT 53 293.3 ± 198.8  
    TT 69 299.5 ± 202.9  
   BDCQ CC 8 48.9 ± 39.2* 0.033
    CT 53 48.0 ± 38.5  
    TT 69 48.8 ± 39.0  
Adjusted Model# rs3735451 HCQ CC 10 759.9 ± 569.6* 0.017
    CT 58 795.9 ± 651.9  
    TT 78 797.0 ± 651.9  
   DHCQ CC 10 519.8 ± 381.6  
    CT 58 553.5 ± 452.8  
    TT 78 554.1 ± 454.0  
   DCQ CC 10 305.6 ± 271.3* 0.047
    CT 58 322.3 ± 239.3  
    TT 78 322.7 ± 241.0  
   BDCQ CC 10 49.7 ± 40.4* 0.005
    CT 58 53.5 ± 52.5  
    TT 78 53.3 ± 52.4  
  1. Note: vs. CT genotype, *P < 0.05 #: Adjusted for duration of use