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Fig. 2 | BMC Medical Genomics

Fig. 2

From: A novel defined risk signature based on pyroptosis-related genes can predict the prognosis of prostate cancer

Fig. 2

Characterization of pyroptosis-related genes at the biological level in tumor. A The heatmap revealed that expression levels of 35 of 52 PRGs in tumor and normal tissues were imbalanced, with red representing high expression and blue representing low expression (Wilcoxon test, *P < 0.05; **P < 0.01; ***P < 0.001). B Correlation network of 35 PRGs differentially expressed between cancer and normal tissues (correlation coefficient > 0.4, with red line representing positive correlation and blue line representing negative correlation). C Genomic changes from 495 PCa samples from TCGA with waterfalls representing information on different PRGs mutations. A note at the bottom of corresponding color indicates different mutation types. The histogram above represents the tumor mutation burden for each sample. The number on the right indicates the mutation frequency. D The location of PRGs at which CNV occurs on chromosome. E The frequency of copy number variation (CNV) for different PRGs indicated that deletion with copy number existed in most PRGs

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