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Table 2 Prevalence and distribution of TERT mutations in cancer genomes. The prevalence of TERT mutations in given as percentage and as total number of cases

From: Direct comparison of the next-generation sequencing and iTERT PCR methods for the diagnosis of TERT hotspot mutations in advanced solid cancers

Cancer type Our study Prevalence of mutations in published literatures
Prevalence of mutations c.1-124C>T (C228T) c.1-146 C>T (C250T)
Urinary bladder 31/47 (66.0%) 24/31 (77.4%) 7/31 (22.6%) 29–100% [3, 6, 7, 35,36,37,38, 51]
Pancreatobiliary 19/127 (15.0%) 16/19 (84.2%) 3/19 (15.8%) 0–7% [5, 9, 42, 52]
Liver 22/41 (53.7%) 19/22 (86.4%) 3/22 (13.6%) 29–65% [35, 39, 40]
Melanoma 12/90 (13.2%) 5/12 (41.7%) 7/12 (58.3%) 60–100% [4, 15, 34]