Direct comparison of the next-generation sequencing and iTERT PCR methods for the diagnosis of TERT hotspot mutations in advanced solid cancers

Table 2 Prevalence and distribution of TERT mutations in cancer genomes. The prevalence of TERT mutations in given as percentage and as total number of cases

Cancer type	Our study			Prevalence of mutations in published literatures
Cancer type	Prevalence of mutations	c.1-124C>T (C228T)	c.1-146 C>T (C250T)	Prevalence of mutations in published literatures
Urinary bladder	31/47 (66.0%)	24/31 (77.4%)	7/31 (22.6%)	29–100% [3, 6, 7, 35,36,37,38, 51]
Pancreatobiliary	19/127 (15.0%)	16/19 (84.2%)	3/19 (15.8%)	0–7% [5, 9, 42, 52]
Liver	22/41 (53.7%)	19/22 (86.4%)	3/22 (13.6%)	29–65% [35, 39, 40]
Melanoma	12/90 (13.2%)	5/12 (41.7%)	7/12 (58.3%)	60–100% [4, 15, 34]

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