Fig. 1

Serum prostate-specific antigen (PSA) and neuron-specific enolase (NSE) levels and chronological treatments. Bone scintigraphy is placed at each time period. Before radium-223 (Ra-223) initiation, a new uptake appeared in the right femoral head. Six courses of Ra-223 did not make a difference in the image, but after platinum-based chemotherapy and twice external beam radiotherapies (EBRTs), a remarkable improvement was observed in the bone scan